Dear Colleagues,

Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism, and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species. PBPK modeling is used in pharmaceutical research and drug development.

PBPK models are compartmental models like many others, but they have a few advantages over so-called "classical" pharmacokinetic models, which are less grounded in physiology. PBPK models can first be used to abstract and eventually reconcile disparate data (from physicochemical or biochemical experiments, in vitro or in vivo pharmacological or toxicological experiments, etc.) They also provide access to internal body concentrations of chemicals or their metabolites, and in particular, the site of their effects can be therapeutic or toxic.

This Special Issue is dedicated to new, cutting-edge examples of the application of PBPK modeling to show its versatility and highlight recent advances in the field. Modeling scientists are cordially invited to share their research covering the full spectrum of PBPK modeling and simulation, including (but not limited to) the pharmacokinetics of special populations (e.g., geriatrics, pediatrics, pregnancy, ICU), the modeling of pathophysiology (e.g., renal impairment, hepatic impairment), drug–gene interactions, drug–drug interactions, the integration of tissue concentration (e.g., by imaging techniques), PBPK covariate modeling, PBPK-based precision dosing, PBPK/PD modeling, PBPK-based Quantitative Systems Pharmacology (QSP) approaches or technical advances.

Dr. Zubida M. Al-Majdoub
Guest Editor

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• physiologically based pharmacokinetic (PBPK) modeling
• drug–drug interactions
• drug–gene interactions
• PBPK-based precision dosing
• PBPK-based Quantitative Systems Pharmacology