Novel Approaches for Optimizing Pharmacotherapy Based on Recent Pharmacokinetic, Pharmacodynamic, and Pharmacogenetic Developments
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 1508
Special Issue Editors
Interests: pharmacokinetics; pharmacodynamics; PK/PD modeling; PBPK modeling; bioanalysis; PDE inhibitors; inflammation
Interests: preclinical pharmacokinetic assessment of pharmacologically active compounds; estimation of hepatic clearance; isolated hepatocytes; isolated perfused liver model; bioanalysis; LC-MS/MS; drug–drug interactions; clinical pharmacokinetics of cytostatic and antimicrobial drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug development is a complex, costly, and time-consuming process. Even if the number of new drugs approved each year is increasing, slow progress is observed in approval of drugs for some disorders, such as neurological or lifestyle diseases, with greater emphasis being placed on anticancer drugs and biologics. Therefore, we should adopt the most effective use of existing drugs supported by innovative analytical, computational, and genetic-based methods.
This Special Issue presents the advances in the optimization of pharmacotherapy observed in recent years as a result of the current progress in pharmacokinetics and pharmacodynamics, the introduction of new sampling and analytical techniques, and the implementation of pharmacogenetic testing in clinical practice. Equally important in this area is the introduction of novel biomarkers of drug response and disease progression, advanced computer-based methods, and PK/PD models that can be used to select an appropriate dose and dosage scheme for an individual patient.
Prof. Dr. Elżbieta Wyska
Dr. Małgorzata Szafarz
Guest Editors
Manuscript Submission Information
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Keywords
- dosage individualization
- TDM
- pharmacogenetics
- PK/PD modeling
- simulations
- software
- biomarkers
