Therapeutic Drug Monitoring for Individualized Cancer Therapy
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Clinical Pharmaceutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 26
Special Issue Editors
Interests: basic pharmacology; dermatology; gastroenterology; clinical pharmacy; pharmacoeconomics
Special Issue Information
Dear Colleagues,
Cancer continues to be one of the greatest global health burdens, despite the advancements in diagnostics and treatment. Targeted therapy has brought significant improvements in tolerability; however, the one-size-fits-all concept remains inappropriate in many cases, as inadequate dosing can lead to toxicity or disease progression. Therapeutic drug monitoring (TDM) as a tool of precision medicine promises treatment tailored to individual needs, especially using advanced pharmacometric methods such as model-informed precision dosing (MIPD). These approaches rely on accurate and sensitive quantification of drugs in complex biological samples followed by a population pharmacokinetic (popPK) and pharmacodynamic (PD) analysis in the context of individual physiological characteristics. Testing the feasibility of TDM for different anticancer drugs is an area of ongoing research, with new evidence surfacing on a daily basis. Both the development of cutting-edge analytical methodology and the PK/PD profiling are essential for further advancement in this field.
We invite you to contribute your original research articles and review papers to this Special Issue dedicated to all aspects of TDM of anticancer drugs: development of novel bioanalytical methods, their application on patient samples, results from clinical PK and PD studies, adherence monitoring, PK simulations, and more. We hope this Special Issue provides a cross-section of the current state in this field, and we are excited to receive your submissions.
Dr. Petra Turčić
Dr. Lu Turković
Guest Editors
Manuscript Submission Information
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Keywords
- personalized medicine
- pharmacometrics
- population pharmacokinetics and pharmacodynamics (PK-PD)
- nonlinear mixed-effects modeling (NONMEM)
- targeted anticancer drugs
- clinical pharmacy and pharmacology
- kinase inhibitors
- monoclonal antibodies (mAbs)
- bioanalytical method development and validation
- (non-)adherence
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