Impact of Lipid Nanoparticle Physicochemical Properties on mRNA Vaccine
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 141
Special Issue Editor
Interests: biomaterials; drug delivery; gene therapy; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As mRNA vaccines extend their applications from infectious diseases to oncology and other therapeutic areas, optimizing lipid nanoparticle (LNP) formulations is critical to enhancing vaccine efficacy, stability, and safety. Key physicochemical properties of LNPs—including lipid structure, particle size, surface charge, lipid composition, and structural characteristics—significantly influence mRNA delivery efficiency and immune response activation. A comprehensive understanding of how these properties affect mRNA delivery, biodistribution, and cellular uptake will facilitate advancements in vaccine design, formulation, and production. This special issue seeks to consolidate leading research and reviews examining the relationship between LNP physicochemical properties and mRNA vaccine performance. We invite original research articles, reviews, and perspectives on a variety of topics, including but not limited to: emerging technologies in LNP design, physicochemical property optimization, structure-function relationships, stability and storage solutions, targeted delivery and biodistribution, and safety and biocompatibility.
We look forward to receiving your contributions.
Prof. Dr. Chuanxu Yang
Guest Editor
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Keywords
- lipid nanoparticle formulation
- ionizable lipids design
- delivery of mRNA vaccines
- sustained/controlled release
- targeted delivery
- stability and storage solutions
- pharmacokinetics and pharmacodynamics
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