Biomaterials for Topical Drug Delivery to the Skin and Wound Healing: New Insights

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 1935

Special Issue Editors

1. The Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
2. The Department of Pharmacology, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
Interests: in vitro skin model; 3D bioprinting; tissue engineering; wound dressings; electrospinning
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Guest Editor
Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
Interests: in vitro skin model; 3D bioprinting; tissue engineering; electrochemical sensors

Special Issue Information

Dear Colleagues,

We invite researchers, scientists, and practitioners to contribute to our upcoming Special Issue focused on “Biomaterials for Topical Drug Delivery to the Skin and Wound Healing: New Insights”. We will explore innovative biomaterials and cutting-edge strategies that enhance the efficiency, safety, and specificity of topical drug delivery and are important for new approaches in the field of wound healing.

We invite researchers to contribute their cutting-edge work in the field of biomaterials for topical drug delivery and wound healing.

Topics of interest include, but are not limited to, the following list.

Biomaterials for Topical Drug Delivery:

  • Novel biomaterials for skin penetration;
  • Advances in controlled-release systems;
  • Nanotechnology in topical drug delivery;
  • Biocompatible carriers for enhanced skin permeability;
  • Formulation strategies for improved drug stability;
  • Therapeutic breakthroughs in dermatological applications;
  • Mechanistic studies on drug interactions with skin barriers.

Wound Healing Biomaterials:

  • Advanced wound healing scaffolds;
  • Bioactive materials for tissue regeneration;
  • Immunomodulatory approaches.

Innovative Wound Dressings:

  • Antimicrobial dressings;
  • Bioresponsive dressings;
  • Scaffolds for chronic wound management.

3D Bioprinting in Dermatology:

  • Printing skin substitutes;
  • Customized tissue constructs;
  • Bioprinted models for drug testing.

Join us in exploring the latest advances in biomaterials and fostering collaboration for the development of transformative solutions in skin health. Together, let’s shape the future of topical drug delivery and wound healing.

Dr. Tina Maver
Dr. Tanja Zidarič
Guest Editors

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Keywords

  • nanotechnology
  • permeability
  • controlled release
  • dermatological applications
  • formulation strategies
  • wound dressings
  • wound healing
  • 3D bioprinting

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Published Papers (1 paper)

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Research

27 pages, 37823 KiB  
Article
Biopolymeric Insulin Membranes for Antimicrobial, Antioxidant, and Wound Healing Applications
by Rocío Aguilar-Vázquez, Alejandra Romero-Montero, María L. Del Prado-Audelo, Lizbeth Cariño-Calvo, Manuel González-Del Carmen, Pablo Adrián Vizcaíno-Dorado, Isaac Hiram Caballero-Florán, Sheila Iraís Peña-Corona, Juan Isaac Chávez-Corona, María Josefa Bernad-Bernad, Jonathan J. Magaña, Hernán Cortés and Gerardo Leyva-Gómez
Pharmaceutics 2024, 16(8), 1012; https://doi.org/10.3390/pharmaceutics16081012 - 30 Jul 2024
Cited by 2 | Viewed by 1461
Abstract
Delayed wound healing increases the wound’s vulnerability to possible infections, which may have lethal outcomes. The treatments available can be effective, but the urgency is not fully encompassed. The drug repositioning strategy proposes effective alternatives for enhancing medical therapies for chronic diseases. Likewise, [...] Read more.
Delayed wound healing increases the wound’s vulnerability to possible infections, which may have lethal outcomes. The treatments available can be effective, but the urgency is not fully encompassed. The drug repositioning strategy proposes effective alternatives for enhancing medical therapies for chronic diseases. Likewise, applying wound dressings as biodegradable membranes is extremely attractive due to their ease of application, therapeutic effectiveness, and feasibility in industrial manufacturing. This article aims to demonstrate the pleiotropic effects during insulin repositioning in wound closure by employing a biopolymeric membrane-type formulation with insulin. We prepared biopolymeric membranes with sodium alginate cross-linked with calcium chloride, supported in a mixture of xanthan gum and guar gum, and plasticized with glycerol and sorbitol. Human insulin was combined with poloxamer 188 as a protein stabilizing agent. Our investigation encompassed physicochemical and mechanical characterization, antioxidant and biological activity through antibacterial tests, cell viability assessments, and scratch assays as an in vitro and in vivo wound model. We demonstrated that our biopolymeric insulin membranes exhibited adequate manipulation and suitable mechanical resistance, transparency, high swelling capability (1100%), and 30% antioxidant activity. Furthermore, they exhibited antibacterial activity (growth inhibition of S. aureus at 85% and P. aeruginosa at 75%, respectively), and insulin promoted wound closure in vitro with a 5.5-fold increase and 72% closure at 24 h. Also, insulin promoted in vivo wound closure with a 3.2-fold increase and 92% closure at 10 days compared with the groups without insulin, and this is the first report that demonstrates this therapeutic effect with two administrations of 0.7 IU. In conclusion, we developed a multifunctional insulin-loaded biopolymeric membrane in this study, with the main activity derived from insulin’s role in wound closure and antioxidant activity, augmented by the antimicrobial effect attributed to the polymer poloxamer 188. The synergistic combination of excipients enhances its usefulness and highlights our innovation as a promising material in wound healing materials. Full article
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