MicroRNAs in Cancer Therapy: Recent Advances and Prospects
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1702
Special Issue Editor
Interests: pharmacogenomics; pharmacoepigenetics; nanomedicine; toxicity of cancer chemotherapy; biological evaluation of natural compounds; cardiovascular diseases
Special Issue Information
Dear Colleagues,
The abnormal expression of microRNAs (miRNAs), which are regulatory small non-coding RNAs, occurs in pathological events such as cancer. Their extraordinary regulatory potential, which enables the regulation of entire signalling networks within the cells, makes them an interesting tool for the development of cancer therapeutics. The pattern of miRNAs expression can be correlated with the cancer type, stage, and other clinical variables. It has been demonstrated that miRNAs are implicated in almost all aspects of cancer biology, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis. A number of miRNAs affect the growth of cancer cells in vitro and in vivo when overexpressed or inhibited. Therefore, cancer cell growth can be controlled by manipulating miRNAs.
In this Special Issue of Pharmaceutics, original articles and comprehensive reviews that present novel anticancer strategies with a focus on miRNAs exhibting experimentally proven therapeutic potential and that discuss recent advances in the technical development and clinical evaluation of miRNA-based therapeutic agents are welcome. These strategies should address the optimization of cancer therapies that could offer remarkable clinical value in the near future. We therefore encourage the submission of articles that focus on the development and validation of various novel anticancer approaches including, but not limited to, synthetic miRNA mimics such as the siRNA-like oligoribonucleotide duplex or chemically modified oligoribonucleotide, and strategies involving miRNA delivery using liposomes, viral vectors and nanoparticles, among others.
Prof. Dr. Luis A. Salazar
Guest Editor
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Keywords
- cancer therapy
- miRNA mimics
- miRNA delivery
- oligoribonucleotide
- siRNA-like oligoribonucleotide
- drug delivery
- therapy resistance
- miRNA antagonists
- viral vectors
- LNA-modified oligonucleotides
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