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Pharmaceutics
Special Issues
Innovative Drug Delivery Systems for Regenerative Medicine, 2nd Edition
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Innovative Drug Delivery Systems for Regenerative Medicine, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1907

Special Issue Editor

Dr. Elise Verron

E-Mail Website
Guest Editor
1. Chemical and Interdisciplinarity, Synthesis, Analysis, Modelisation, CEISAM UMR CNRS 6230, University of Nantes, 44300 Nantes, France
2. Department of Elaboration and Evaluation of Drugs, Faculty of Pharmaceutical and Biological Sciences, University of Nantes, 44000 Nantes, France
Interests: regenerative medicine; tissue engineering; drug delivery; controlled release; biomaterial; nanotechnology; innovative design and processing; pre-clinical studies; clinical studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Regenerative medicine seeks to treat patients with dysfunctional tissue, and the development of innovative biomaterial-based technologies is the subject of intensive research addressing this issue. Regarding active compound delivery systems, the spatiotemporal control of the release profile represents a real challenge in terms of optimal activity, stability and safety and would offer personalized medicine. In response to these challenges, sophisticated delivery systems are emerging, and this Special Issue aims to review recent advances in this field.

Focusing on strategies for spatiotemporal control of drug delivery within scaffolds for tissue engineering, major mechanisms and critical factors affecting release profiles will be highlighted, as well as nanotechnologies and mathematical model contributions to these new therapeutic approaches.

This Special Issue aims to cover all the steps from bench to bedside, starting from basic principles underlaying the design of delivery vehicles up to regulatory frameworks governing clinical applications.

Dr. Elise Verron
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • tissue engineering
  • drug delivery
  • controlled release
  • biomaterial
  • nanotechnology
  • innovative design and processing
  • pre-clinical studies
  • clinical studies

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Related Special Issue

Published Papers (1 paper)

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Research

15 pages, 22332 KiB  
Article
Using Hybrid MnO2-Au Nanoflowers to Accelerate ROS Scavenging and Wound Healing in Diabetes
by Ning Jiang, Xinwei Liu, Baiyan Sui, Jiale Wang, Xin Liu and Zun Zhang
Pharmaceutics 2024, 16(10), 1244; https://doi.org/10.3390/pharmaceutics16101244 - 25 Sep 2024
Cited by 1 | Viewed by 1433
Abstract
Objectives: Excessive reactive oxygen species (ROS) in diabetic wounds are major contributors to chronic wounds and impaired healing, posing significant challenges in regenerative medicine. Developing innovative drug delivery systems is crucial to address these issues by modifying the adverse microenvironment and promoting effective [...] Read more.
Objectives: Excessive reactive oxygen species (ROS) in diabetic wounds are major contributors to chronic wounds and impaired healing, posing significant challenges in regenerative medicine. Developing innovative drug delivery systems is crucial to address these issues by modifying the adverse microenvironment and promoting effective wound healing. Methods: Herein, we designed a novel drug delivery platform using manganese dioxide nanoflower hybridized gold nanoparticle composites (MnO2-Au) synthesized via a hydrothermal reaction, and investigated the potential of MnO2-Au nanoflowers to relieve the high oxidative stress microenvironment and regulate diabetic wound tissue healing. Results: This hybrid material demonstrated superior catalytic activity compared to MnO2 alone, enabling the rapid decomposition of hydrogen peroxide and a substantial reduction in ROS levels within dermal fibroblasts. The MnO2-Au nanoflowers also facilitated enhanced dermal fibroblast migration and Col-I expression, which are critical for tissue regeneration. Additionally, a hydrogel-based wound dressing incorporating MnO2-Au nanoflowers was developed, showing its potential as an intelligent drug delivery system. This dressing significantly reduced oxidative stress, accelerated wound closure, and improved the quality of neonatal epithelial tissue regeneration in a diabetic rat skin defect model. Conclusions: Our findings underscore the potential of MnO2-Au nanoflower-based drug delivery systems as a promising therapeutic approach for chronic wound healing, particularly in regenerative medicine. Full article
(This article belongs to the Special Issue Innovative Drug Delivery Systems for Regenerative Medicine, 2nd Edition)
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