Nano-Based Delivery Systems for Topical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1523

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Domagojeva 2, 10000 Zagreb, Croatia
Interests: topical drug delivery; nanomedicine; spray-drying; biopharmaceutics

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Guest Editor
School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK
Interests: nanoparticles; topical delivery; liposomes; lipid nanocapsules; nanocrystals; solid lipid nanoparticles; nanostructured lipid carriers; nanoemulsions; polymeric nanoparticles

Special Issue Information

Dear Colleagues,

Nanotechnology had gained momentum again after the emergence of the COVID-19 pandemic, with several vaccines being developed with nanoparticle delivery systems. The work of nanotechnology has been widely investigated for systemic administration; however, the nature of the nanometric size range highlights the great promise nanotechnology can offer to topical drug administration. The extreme small particle size that enables tight adherence to surfaces, complete coverage of the application area, and, in parallel, the versatility of sizes and compositions for better interaction and penetration upon topical application have extended nanoparticles usage from cosmetics to pharmaceuticals and from small to large molecules. This Special Issue aims to gather a selection of novel research in the area of nanoparticles’ topical delivery for pharmaceutical scientists in academia and industry to explore nanoparticles in topical delivery further and in more depth, making use of those unique systems to tackle complex topical diseases such psoriasis, atopic dermatitis, conjunctivitis, and otitis.  

I am pleased to invite you to contribute to this Special Issue, entitled “Nano-Based Delivery Systems for Topical Applications”. In this Special Issue, we aim to shed light on novel topical drug delivery cases that are based on the design and application of nanotechnology from formulation development to in vitro and in vivo preclinical formulation assessment. The scope of this Special Issue is to cover the main topical diseases of interest, such as topical caners, topical autoimmune diseases, and the use of nanoparticles in cosmetics.

In this Special Issue, original research articles and reviews are welcome to be submitted. Research areas may include, but are not limited to, the following:

  1. Nanoparticles designed for better skin interaction;
  2. Nanoparticles for drug delivery to nails;
  3. Nanoparticles for topical ocular conditions;
  4. The use of nanoparticles as drug delivery systems for topical cancers and autoimmune diseases, such as psoriasis.

I look forward to receiving your contributions.

Prof. Dr. Jelena Filipović-Grčić
Dr. Taher Hatahet
Guest Editors

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Keywords

  • nanoparticles
  • topical delivery
  • lipid-based nanoparticles
  • polymeric nanoparticles
  • psoriasis
  • drug delivery to nails
  • topical ocular diseases
  • skin cancers
  • nanoparticles in cosmetics

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Published Papers (1 paper)

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Review

18 pages, 1356 KiB  
Review
Modulating Polyphenol Activity with Metal Ions: Insights into Dermatological Applications
by Oana Cioanca, Ionut-Iulian Lungu, Denisa Batir-Marin, Andreea Lungu, George-Alexandru Marin, Riana Huzum, Alina Stefanache, Nazim Sekeroglu and Monica Hancianu
Pharmaceutics 2025, 17(2), 194; https://doi.org/10.3390/pharmaceutics17020194 - 4 Feb 2025
Cited by 1 | Viewed by 1071
Abstract
Background: The skin represents the first barrier of defense, and its integrity is crucial for overall health. Skin wounds present a considerable risk seeing how their progression is rapid and sometimes they are caused by comorbidities like diabetes and venous diseases. Nutraceutical combinations [...] Read more.
Background: The skin represents the first barrier of defense, and its integrity is crucial for overall health. Skin wounds present a considerable risk seeing how their progression is rapid and sometimes they are caused by comorbidities like diabetes and venous diseases. Nutraceutical combinations like the ones between polyphenols and metal ions present considerable applications thanks to their increased bioavailability and their ability to modulate intrinsic molecular pathways. Methods: The research findings presented in this paper are based on a systematic review of the current literature with an emphasis on nanotechnology and regenerative medicine strategies that incorporate polyphenols and metallic nanoparticles (NPs). The key studies which described the action mechanisms, efficacy, and safety of these hybrid formulations were reviewed. Results: Nanocomposites of polyphenol and metal promote healing by activating signaling pathways such as PI3K/Akt and ERK1/2, which in turn improve fibroblast migration and proliferation. Nanoparticles of silver and copper have antibacterial, angiogenesis-promoting, inflammation-modulating capabilities. With their ability to induce apoptosis and restrict cell growth, these composites have the potential to cure skin malignancies in addition to facilitating wound healing. Conclusions: Nanocomposites of polyphenols and metals provide hope for the treatment of cancer and chronic wounds. Their antimicrobial capabilities, capacity to modulate inflammatory responses, and enhancement of fibroblast activity all point to their medicinal potential. Furthermore, these composites have the ability to decrease inflammation associated with tumors while simultaneously inducing cell death in cancer cells. Clarifying their mechanisms, guaranteeing stability, and enhancing effective delivery techniques for clinical usage should be the focus of future studies. Full article
(This article belongs to the Special Issue Nano-Based Delivery Systems for Topical Applications)
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