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Pharmaceutics
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Advances in Drug Delivery Systems for Transmucosal Routes Applied in...
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Advances in Drug Delivery Systems for Transmucosal Routes Applied in the Treatment of Infectious and Chronic Degenerative Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 873

Special Issue Editor

Prof. Dr. Fernanda Isadora Boni

E-Mail Website
Guest Editor
Department Pharmacy, University of São Paulo (USP), Av. Prof. Lineu Prestes 580, Bloco 13, São Paulo 05508-900, SP, Brazil
Interests: drug delivery system; polymers; mucoadhesion; nanotechnology; microparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The treatment of infectious and chronic diseases is complex due to factors such as drug resistance, demand for long-term management, severe adverse effects affecting patient treatment compliance, and low efficacy/dose. These challenges underscore the importance of research for the development of more selective, specific, and effective therapies. In this context, pharmaceutical technology can be a valuable tool for designing drug delivery systems aimed at mucosa-coated routes, capable of modulating mucous–mucosal interactions and promoting, for example, increased permeation and/or cellular internalization. This Special Issue aims to deepen the understanding of recent advances in the development of drug delivery systems, with a focus on transmucosal applications and their benefits in the treatment of infectious and chronic degenerative diseases.

Submitted papers can address a wide range of topics, including, but not limited to, the following: the development of specific formulations to optimize drug delivery and/or mucosal permeation; mechanisms of drug absorption and transport across mucosal membranes; clinical and therapeutic applications of innovative drug delivery systems in infectious and chronic degenerative diseases; and studies on the efficacy, safety, and tolerability of transmucosal delivery systems.

We invite all researchers, academics, and professionals interested in this field to contribute their work to this Special Issue. We believe that this initiative will significantly contribute to advancing knowledge in this crucial field.

Prof. Dr. Fernanda Isadora Boni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mucosal permeation
  • drug delivery system development
  • biological behavior
  • mucoadhesion
  • mucopermeation
  • mucosal route of administration

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Published Papers (1 paper)

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Research

31 pages, 3594 KiB  
Article
Development and Characterization of a Primary Ciliated Porcine Airway Model for the Evaluation of In Vitro Mucociliary Clearance and Mucosal Drug Delivery
by Janik Martin, Veronika Neubauer, Rebecca Rittersberger, Simon Treitler, Patrick Kopp, Cemre Günday, Iman Shrimo, Annabelle Dabbars, Frank Rosenau, Akif Emre Türeli, Nazende Günday-Türeli, Oliver Haedicke-Peters and Katharina Schindowski
Pharmaceutics 2025, 17(4), 462; https://doi.org/10.3390/pharmaceutics17040462 - 2 Apr 2025
Viewed by 438
Abstract
Background/Objectives: In vitro models play a crucial role in preclinical respiratory research, enabling the testing and screening of mucosal formulations, dosage forms, and inhaled drugs. Mucociliary clearance (MCC) is an essential defense mechanism in mucosal drug delivery but is often impaired in [...] Read more.
Background/Objectives: In vitro models play a crucial role in preclinical respiratory research, enabling the testing and screening of mucosal formulations, dosage forms, and inhaled drugs. Mucociliary clearance (MCC) is an essential defense mechanism in mucosal drug delivery but is often impaired in respiratory diseases. Despite its importance, standardized in vitro MCC assays are rarely reported. Furthermore, many published methods primarily measure cilia beat frequency (CBF), which requires high-speed cameras that are not accessible to all laboratories. Therefore, this study aimed to develop a physiologically relevant, differentiated in vitro model of the respiratory epithelium that incorporates both beating cilia and functional MCC. We chose porcine airway mucosa as an alternative to human tissue due to ethical considerations and limited availability. The established model is designed to provide a reproducible and accessible method for a broad range of research laboratories. Methods: The previously published tracheal mucosal primary cell (TMPC DS) model, derived from porcine tissue, lacked the presence of beating cilia, which are crucial for effective MCC analysis. For accurate MCC assessment, beating cilia are essential as they play a key role in mucus clearance. To address this limitation, the here-described ciliated tracheal mucosal primary cell (cTMPC) model was developed. cTMPCs were isolated from porcine tissue and cultured under air–liquid interface (ALI) conditions for 21 days to promote differentiation. This model was evaluated for cell morphology, tight junction formation, ciliated and mucus-producing cells, barrier function, gene expression, and tracer/IgG transport. MCC and the model’s suitability for standardized MCC assays were assessed using an inverted microscope. In contrast to the TMPC DS model, which lacked beating cilia and thus could not support MCC analysis, the cTMPC model allows for comprehensive MCC studies. Results: The developed differentiated in vitro model demonstrated key structural and functional features of the respiratory epithelium, including well-differentiated cell morphology, tight junction integrity, ciliated and mucus-producing cells, and effective barrier function. Functional MCC was observed, confirming the model’s potential for standardized clearance assays. Conclusions: This differentiated in vitro model closely replicates the structural and functional characteristics of in vivo airways. It provides a valuable platform for studying mucociliary clearance, toxicology, drug uptake, and evaluating mucosal formulations and dosage forms in respiratory research. Full article
(This article belongs to the Special Issue Advances in Drug Delivery Systems for Transmucosal Routes Applied in the Treatment of Infectious and Chronic Degenerative Diseases)
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