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Pharmaceutics
Special Issues
Feature Reviews in Pharmaceutical Technology, Manufacturing and Devices
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Feature Reviews in Pharmaceutical Technology, Manufacturing and Devices

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 30 March 2026 | Viewed by 726

Special Issue Editor

Prof. Dr. Thierry Vandamme

E-Mail Website
Guest Editor
Laboratory for the Conception and Application of Bioactive Molecules, Faculty of Pharmacy, University of Strasbourg, 67400 Illkirch-Graffenstaden, France
Interests: microencapsulation; nanoemulsions; biopharmacy; formulation; pharmaceutical engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmaceutics is pleased to announce a Special Issue on "Feature Reviews in Pharmaceutical Technology, Manufacturing and Devices." This Special Issue aims to provide a platform for comprehensive reviews on the latest advances, challenges, and future directions in pharmaceutical technology, manufacturing processes, and drug delivery devices. Topics of interest include innovations in drug formulation, nanotechnology applications, continuous manufacturing, process optimization, quality control, regulatory strategies, and the development of advanced drug delivery devices (e.g., injectors, inhalers, and wearable devices). Special emphasis will be placed on the integration of emerging technologies, such as 3D printing, artificial intelligence, machine learning, and automation, to enhance product design, manufacturing efficiency, and patient outcomes. Contributions should aim to synthesize current knowledge, identify trends, and provide insights into translational and clinical applications.

We invite researchers and industry professionals to contribute feature reviews that critically evaluate advancements in pharmaceutical technology, manufacturing, and devices, promoting innovation and collaboration in these rapidly evolving fields.

Prof. Dr. Thierry Vandamme
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmaceutical technology
  • drug manufacturing
  • nanotechnology
  • continuous manufacturing
  • drug delivery devices
  • 3D printing
  • artificial intelligence
  • wearable devices
  • process optimization

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Published Papers (1 paper)

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Research

12 pages, 580 KB  
Article
A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology
by Philippe-Henri Secretan, Maxime Annereau and Bernard Do
Pharmaceutics 2025, 17(9), 1202; https://doi.org/10.3390/pharmaceutics17091202 - 16 Sep 2025
Viewed by 437
Abstract
Background/Objectives: Hospital compounding is essential for the delivery of patient-tailored therapies—particularly for pediatric and oncology patients and other groups requiring precise dosing. Its role is expected to grow as, for instance, the UK MHRA’s new Guidance on Decentralised Manufacturing promotes alternative manufacturing [...] Read more.
Background/Objectives: Hospital compounding is essential for the delivery of patient-tailored therapies—particularly for pediatric and oncology patients and other groups requiring precise dosing. Its role is expected to grow as, for instance, the UK MHRA’s new Guidance on Decentralised Manufacturing promotes alternative manufacturing pathways that integrate hospital preparation units. However, drug substances that remain stable in commercial oral formulations may undergo rapid degradation under alternative conditions (e.g., aqueous suspension, light exposure, or in the presence of specific excipients). Despite these risks, formulation strategies in hospital compounding often rely on empirical practices and lack structured guidance regarding stability, impurity control, and reproducibility. Methods: This study proposes a risk-based scientific framework for formulation design, integrating degradation profiling with predictive toxicology. Potential degradation pathways (hydrolytic, oxidative, and photolytic) are systematically identified through forced-degradation studies combined with ab initio modeling. These risks are translated into formulation strategies using a structured decision tree encompassing solvent selection, pH adjustment, excipient compatibility, and packaging considerations, even in the absence of a pharmacopeial monograph. The toxicological relevance of degradation products is evaluated using in silico approaches aligned with ICH M7 guidelines, thereby defining critical quality attributes (cQAs) and critical process parameters (CPPs). Results: The applicability of the framework is demonstrated through hospital compounding case studies, with further extension toward advanced applications such as semi-solid extrusion (SSE) 3D printing. Conclusions: By integrating mechanistic understanding of drug degradation into formulation planning, the proposed framework enhances the safety, reproducibility, and quality of compounded preparations. This approach reinforces Good Preparation Practices (GPPs) and is consistent with international quality-by-design (QbD) principles in the context of personalized medicine. Full article
(This article belongs to the Special Issue Feature Reviews in Pharmaceutical Technology, Manufacturing and Devices)
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