Advances in Targeted Therapy for Gastrointestinal Cancers

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 6

Special Issue Editors


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Guest Editor
1. Department of Oncology, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
2. School of Dental Medicine, University of Zagreb, Gundulićeva 5, 10000 Zagreb, Croatia
Interests: hepatobiliary cancers; colorectal cancer; gastric cancer; immunotherapy; targeted therapy

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Guest Editor
1. Tumor Clinic, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia
2. School of Medicine, University of Rijeka, 51000 Rijeka, Croatia
Interests: gastrontestinal cancers; skin cancers; palliative care

Special Issue Information

Dear Colleagues,

This Special Issue, “Advances in Targeted Therapy for Gastrointestinal Cancers”, aims to highlight recent progress and emerging strategies in the development of targeted therapies for gastrointestinal (GI) malignancies. GI cancers, including those of the esophagus, stomach, pancreas, liver, bile ducts, small intestines, colorectum, and anus, represent a significant global health burden. In recent years, we have witnessed the development of targeted therapies and immunotherapies, which dramatically improved the outcomes for many patients. However, many challenges remain, as only a small subset of GI cancer patients benefits from currently approved drugs. Furthermore, due to complex tumor biology, both primary and acquired resistance frequently occur. Along with new medications, there is also a need for better prognostic and predictive biomarkers. 

This Issue welcomes original research articles, reviews, and short communications that address novel targets, mechanisms of drug resistance, biomarker discovery, clinical trial results, and translational approaches in the field of GI cancer therapeutics. By gathering cutting-edge findings and expert perspectives, this Special Issue seeks to foster scientific exchange and accelerate the development of more effective, personalized treatments for patients with gastrointestinal cancers.

Dr. Juraj Prejac
Dr. Marin Golčić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • targeted therapy
  • gastrointestinal cancers
  • molecular targets
  • drug resistance
  • biomarkers
  • immunotherapy
  • precision medicine
  • translational research
  • clinical trials
  • tumor microenvironment

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Published Papers

This special issue is now open for submission.
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