The Regulatory Roles of the Gut Microbiota in Multisystem Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 3
Special Issue Editors
2. Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy
Interests: autoinflammatory diseases; metabolic storage diseases; gut–brain axis
Interests: clinical and cellular immunology; microbiota and the immune system: crosstalk in health and diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biomedical science is currently witnessing a turning point—the so-called microbiota revolution. Accumulating evidence highlights the pivotal role of the microbiota in multisystem disease pathophysiology, leading to more awareness and ongoing research in this field. Clarifying this complex interaction can enhance our knowledge and potentially facilitate the development of increasingly precise, patient-targeted therapeutic strategies.
The focus in research has shifted from analyzing bacterial populations to studying broader aspects of microbial elements. Of these, bacteriophages, particularly engineered ones, are proving significant, being promoted as preventive and therapeutic agents.
This Special Issue aims to garner high-quality contributions that examine the importance of the microbiota in common and less common diseases, with particular emphasis on internal medicine. The improved survival rates of patients with inherited metabolic diseases, such as Fabry disease and phenylketonuria, pose new clinical challenges that require innovative pathophysiological insights and new treatment approaches.
We welcome original research articles, reviews, and case-based discussions of the diagnostic, therapeutic, and translational importance of the microbiota. They can be presented as mechanistic observations, clinical applications, and novel conceptual treatment strategies—varying from probiotics and postbiotics to bacteriophage and microbiota-guided treatments.
The Special Issue seeks to address the challenges and emerging opportunities in this novel and rapidly expanding field.
Dr. Mario Caldarelli
Dr. Rossella Cianci
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- microbiota
- multisystem diseases
- bacteriophage therapy
- metabolic disorders
- precision medicine
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