Special Issue "Small Molecules as Antimicrobials"

A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: 1 December 2020.

Special Issue Editor

Prof. Poce Giovanna
Website
Guest Editor
Department of Chemistry and Technology of Drugs (DCTF), Sapienza University of Rome, Rome, Italy
Interests: Medicinal chemistry; drug development; antimycobacterials; antibacterials

Special Issue Information

Dear Colleagues,

The World Health Organization (WHO) announced antimicrobial resistance (AMR) as a major threat to public health. The rapid development and spread of new resistance mechanisms has made many antimicrobials useless in treating clinically ill patients. Even medical procedures such as major surgery, organ transplantation, and cancer chemotherapy have become very risky in the absence of effective antimicrobials for prevention and treatment of infections. Therefore, there is an urgent need for new, better, and more effective antimicrobials.

We invite authors to submit original research and review articles related to up-to-date and ongoing research focusing on the development and evaluation of potential new antimicrobial agents, as well as on the investigation of improved delivery protocols of both existing and new antimicrobial agents. We aim to highlight research covering all stages of investigation, such as in silico studies, synthesis efforts, in vitro studies, and in vivo evaluations.

Potential topics include, but are not limited to:

  • Development and testing of novel and effective antimicrobial agents;
  • Antimicrobial agents active against drug-resistant forms;
  • Recent advances in antimicrobial drug delivery.

Prof. Poce Giovanna
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal chemistry
  • antimycobacterials
  • antibacterials

Published Papers (1 paper)

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Review

Open AccessReview
Polymyxin Delivery Systems: Recent Advances and Challenges
Pharmaceuticals 2020, 13(5), 83; https://doi.org/10.3390/ph13050083 - 29 Apr 2020
Abstract
Polymyxins are vital antibiotics for the treatment of multiresistant Gram-negative ESKAPE pathogen infections. However, their clinical value is limited by their high nephrotoxicity and neurotoxicity, as well as their poor permeability and absorption in the gastrointestinal tract. This review focuses on various polymyxin [...] Read more.
Polymyxins are vital antibiotics for the treatment of multiresistant Gram-negative ESKAPE pathogen infections. However, their clinical value is limited by their high nephrotoxicity and neurotoxicity, as well as their poor permeability and absorption in the gastrointestinal tract. This review focuses on various polymyxin delivery systems that improve polymyxin bioavailability and reduce drug toxicity through targeted and controlled release. Currently, the most suitable systems for improving oral, inhalation, and parenteral polymyxin delivery are polymer particles, liposomes, and conjugates, while gels, polymer fibers, and membranes are attractive materials for topical administration of polymyxin for the treatment of infected wounds and burns. In general, the application of these systems protects polymyxin molecules from the negative effects of both physiological and pathological factors while achieving higher concentrations at the target site and reducing dosage and toxicity. Improving the properties of polymyxin will be of great interest to researchers who are focused on developing antimicrobial drugs that show increased efficacy and safety. Full article
(This article belongs to the Special Issue Small Molecules as Antimicrobials)
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