Exploring Natural Products with Antioxidant and Anticancer Properties

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 2779

Special Issue Editors


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Guest Editor
Faculty of Health Sciences (FCS), Post-Graduate Program in Health Sciences, Universidade Federal da Grande Dourados (UFGD), Dourados, MS, Brazil
Interests: ethnobotany; ethnopharmacology; anti-cancer; organoids models; anti-inflammatory
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Universidade Federal da Grande Dourados (UFGD), Dourados, MS, Brazil
Interests: antioxidants; cytotoxicity; antitumor action; cancer and prospection of bioactive molecules of natural and synthetic origin
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer remains the second foremost global cause of mortality. It is estimated that by 2030 cancer would lead to almost 13 million deaths worldwide.  Moreover, cancer therapies are constrained by the emergence of drug resistance and other associated challenges.  Undoubtedly, there is a need for new drugs which might involve combinations with natural compounds for better outcomes.  Since oxidation has been implicated in the progression and development of cancer, antioxidants have been suggested as one of the viable solutions in the treatment of cancer. This is because antioxidants play significant roles in the preservation of cellular integrity, and therefore, a crucial role in sustaining the homeostasis of the host immune system.

In this Special Issue, we welcome submissions of well-designed studies, relying on scientific methods and statistical analysis, that explore natural products—be it from plants, fungus, animals or other sources—which possess anticancer and antioxidant properties. 

Dr. Sikiru Olaitan Balogun
Dr. Edson Lucas Dos Santos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant
  • anticancer
  • neoplasms
  • natural products
  • cytotoxicity

Published Papers (2 papers)

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Research

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14 pages, 2489 KiB  
Article
Regulatory Effect of Ficus carica Latex on Cell Cycle Progression in Human Papillomavirus-Positive Cervical Cancer Cell Lines: Insights from Gene Expression Analysis
by Muharrem Okan Cakir, Ugur Bilge, Arshia Ghanbari and G. Hossein Ashrafi
Pharmaceuticals 2023, 16(12), 1723; https://doi.org/10.3390/ph16121723 - 12 Dec 2023
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Abstract
Cervical cancer presents a significant global health concern with high-risk human papillomaviruses (HPVs) identified as the main cause of this cancer. Although current treatment methods for cervical cancer can eliminate lesions, preventing metastatic spread and minimizing tissue damage remain a major challenge. Therefore, [...] Read more.
Cervical cancer presents a significant global health concern with high-risk human papillomaviruses (HPVs) identified as the main cause of this cancer. Although current treatment methods for cervical cancer can eliminate lesions, preventing metastatic spread and minimizing tissue damage remain a major challenge. Therefore, the development of a safer and innovative therapeutic approach is of the utmost importance. Natural products like fig latex, derived from the Ficus carica tree, have demonstrated promising anti-cancer properties when tested on cervical cancer cell lines. However, the specific mechanisms by which fig latex exerts its effects are still unknown. In this study, we conducted RNA-Seq analysis to explore how fig latex may counteract carcinogenesis in HPV-positive cervical cancer cell lines, namely, CaSki (HPV type 16-positive) and HeLa (HPV type 18-positive). Our results from this investigation indicate that fig latex influences the expression of genes associated with the development and progression of cervical cancer, including pathways related to “Nonsense-Mediated Decay (NMD)”, “Cell Cycle regulation”, “Transcriptional Regulation by TP53”, and “Apoptotic Process”. This selective impact of fig latex on cancer-related pathways suggests a potential novel therapeutic approach for HPV-related cervical cancer. Full article
(This article belongs to the Special Issue Exploring Natural Products with Antioxidant and Anticancer Properties)
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Review

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47 pages, 6532 KiB  
Review
Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy
by Mohamed El Oirdi
Pharmaceuticals 2024, 17(6), 692; https://doi.org/10.3390/ph17060692 (registering DOI) - 27 May 2024
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Abstract
There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in a broad range of characteristics and biological effects. Polyphenols can be found in a variety of foods and drinks, including fruits, cereals, tea, and coffee. Studies both [...] Read more.
There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in a broad range of characteristics and biological effects. Polyphenols can be found in a variety of foods and drinks, including fruits, cereals, tea, and coffee. Studies both in vitro and in vivo, as well as clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, and health advantages. Dietary polyphenols have demonstrated the potential to prevent many health problems, including obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, and neurological diseases. In this paper, the protective effects of polyphenols and the mechanisms behind them are investigated in detail, citing the most recent available literature. This review aims to provide a comprehensive overview of the current knowledge on the role of polyphenols in preventing and managing chronic diseases. The cited publications are derived from in vitro, in vivo, and human-based studies and clinical trials. A more complete understanding of these naturally occurring metabolites will pave the way for the development of novel polyphenol-rich diet and drug development programs. This, in turn, provides further evidence of their health benefits. Full article
(This article belongs to the Special Issue Exploring Natural Products with Antioxidant and Anticancer Properties)
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