Chirality: The Important Factor for Drug Discovery and Development
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 December 2024 | Viewed by 1498
Special Issue Editors
Interests: chiral drugs; natural products; structure elucidation; chiral sensing; quantum-chemical calculation; chiroptical spectroscopy
Interests: chiral drugs; natural products; chiral resolution; organic synthesis; methodology development; reaction mechanism
Special Issue Information
Dear Colleagues,
Chirality is a neglectable factor affecting the biological behavior of different stereoisomers and has attracted great attention during the process of novel drug discovery and development. In 2022, more than 70% of the new chemical entities approved by the FDA are chiral. In addition to point chirality, axial chirality, such as atropisomerism, is also common in drugs.
Over the last two decades, great achievements have been made in the field of asymmetric synthesis of chiral drugs and their intermediates catalyzed by either metal complexes or enzymes. The emergence of new materials including metal organic frames provides more choices of stationary phases for chiral resolution and chiral analysis. Meanwhile, with the development of quantum-chemical theory and computing power, the characterization of stereochemical structures has been greatly facilitated with the aid of NMR and chiroptical spectroscopic techniques.
In the Special Issue titled "Chirality: The Important Factor for Drug Discovery and Development", both reviews and original articles are invited. Topics include all aspects of chiral drug research, i.e., asymmetric synthesis, chiral resolution, chiral analysis, chiroptical spectroscopy, and biological assessment of stereoisomers. The collection of manuscripts will be published as a Special Issue of the journal.
Prof. Dr. Li Li
Dr. Li Xuqin
Dr. Ma Tao
Guest Editors
Manuscript Submission Information
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Keywords
- chiral drugs
- chiral natural products
- chiral resolution
- asymmetric synthesis
- chiral spectroscopy
- chiral impurities
- atropisomerism
- chiral analysis
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