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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antimicrobial Peptide Assemblies
edited by
submission deadline 31 Dec 2025 | Viewed by 177 | Submission Open
Keywords: peptides; peptide hybrids; peptide conjugates; self-assembly; stimuli-responsiveness; antimicrobial activity
(This special issue belongs to the Section Chemical Biology)
Phenotypic Screening for Drug Development and Discovery
edited by Xiang Li
submission deadline 31 Dec 2025 | Viewed by 175 | Submission Open
Keywords: phenotypic screening; drug discovery; target deconvolution; disease models; high-throughput screening; mechanism of action; translational research
(This special issue belongs to the Section Medicinal Chemistry)
Application of Vibrational Spectroscopy Coupled with Chemometric Tools submission deadline 31 Dec 2025 | Viewed by 173 | Submission Open
Keywords: vibrational spectroscopy; chemometrics; quantitative analysis; qualitative analysis; NIR spectroscopy; IR spectroscopy; Raman spectroscopy
(This special issue belongs to the Section Analytical Chemistry)
Unique Heterocycles for Drug Discoveries
edited by
submission deadline 31 Dec 2025 | Viewed by 169 | Submission Open
Keywords: heterocyclic compound; heterocyclic chemistry; medicinal chemistry; drug discovery; synthetic methodologies; drug design
(This special issue belongs to the Section Organic Chemistry)
Natural Products for Chronic Disease: Mechanisms and Applications
edited by and
submission deadline 31 Dec 2025 | Viewed by 164 | Submission Open
Keywords: natural products; chronic diseases; mechanism; herbal compound; drug delivery system; molecular modification
(This special issue belongs to the Section Natural Products Chemistry)
Synthesis and Application of Chalcogen-Containing Organic Compounds submission deadline 31 Dec 2025 | Viewed by 163 | Submission Open
Keywords: organoselenium compounds; organotellurium compounds; organosulfur compounds; electrophilic chalcogenation; nucleophilic chalcogenation; organochalcogen compounds in material science; elemental chalcogen; C– X bond formation (X = S; Se; Te); pharmacological properties
(This special issue belongs to the Section Organic Chemistry)
Applications of Natural Polymers in Biomedicine submission deadline 31 Dec 2025 | Viewed by 161 | Submission Open
Keywords: polymer biomaterials; biopolymers; proteins; polysaccharides; gels; hydrogels; scaffolds; films
(This special issue belongs to the Section Medicinal Chemistry)
Design, Synthesis and Applications of Fluorescent Probes
edited by and
submission deadline 31 Dec 2025 | Viewed by 161 | Submission Open
Keywords: fluorescent probes; bioimaging; design synthesis; molecular imaging; cell biology; disease mechanisms; diagnostic imaging; drug discovery; biocompatibility
(This special issue belongs to the Section Medicinal Chemistry)
Bioavailability of Bioactive Food Compounds submission deadline 31 Dec 2025 | Viewed by 156 | Submission Open
Keywords: bioactivity; bioavailability; in vitro; metabolism; gastrointestinal models; dietary phytochemicals; food processing technology; non-thermal treatment
(This special issue belongs to the Section Food Chemistry)
Synthesis and Application of Nanomaterials for Bio-Based and Environmental Pollution Molecules Detection and Purification
edited by and Gina M. Chiarella
submission deadline 31 Dec 2025 | Viewed by 152 | Submission Open
Keywords: nano-enabled environmental cleanup; sustainable nanotechnology; toxic ion sequestration; environmental remediation; nano compound synthesis; green; eco-friendly nanomaterials as catalysis; water; food; and soil safety
(This special issue belongs to the Section Nanochemistry)
Feature Review Papers in Electrochemistry, 2nd Edition submission deadline 31 Dec 2025 | Viewed by 152 | Submission Open
Keywords: electrochemical science; electrochemical technology; environmental applications; new materials; energy conversion; energy storage; electrocatalysis; combined electrochemical technologies
(This special issue belongs to the Section Electrochemistry)
Applications of Advanced Functional Materials: Electrocatalysis and Energy submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open
Keywords: functional nanomaterials; advanced catalysts; hydrogen evolution reaction (HER); sustainable energy; electrocatalysis; energy conversion
(This special issue belongs to the Section Materials Chemistry)
Advances in Heterogeneous Catalysis for Green Chemistry
edited by Chen Li, and
submission deadline 31 Dec 2025 | Viewed by 147 | Submission Open
Keywords: green chemistry; heterogeneous catalysis; photocatalysis; electrocatalysis; thermal catalysis
(This special issue belongs to the Section Green Chemistry)
Tailored Fluorescent Probes for Selective Recognition of Heavy Metal Species
edited by
submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open
Keywords: fluorescent probes; heavy metal detection; selective recognition; multi-target sensing; environmental monitoring; bioimaging; food safety; sensor design
(This special issue belongs to the Section Analytical Chemistry)
Molecular Spectroscopy and Molecular Structure
edited by , and Yukihiro Ozaki
submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open
Keywords: molecular spectroscopy; molecular structure; applications in biological sciences; applications in materials science; molecular interaction; hydrogen bonds; methodological development; quantum chemical calculation
(This special issue belongs to the Section Photochemistry)
Transition Metal Complexes in Cancer Therapy: Beyond Platinum
edited by Wai Lun Man
submission deadline 31 Dec 2025 | Viewed by 143 | Submission Open
Keywords: anticancer drugs; transition metal complexes; inorganic chemistry; medicinal chemistry; chemotherapy
(This special issue belongs to the Section Cross-Field Chemistry)
Current Development Prospects of Novel Nanocatalysts
edited by Fengyu Gao
submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open
Keywords: novel nanocatalysts; pollutant purification; environmental catalysis technology; precious metals; metal/alloys; metal oxides; non-metallic materials; environmental protection; gas purification; wastewater treatment; soil remediation; solid waste management; carbon neutrality
(This special issue belongs to the Section Green Chemistry)
Plasma Catalysis Method in Catalytic Process
edited by and Debtanu Maiti
submission deadline 31 Dec 2025 | Viewed by 138 | Submission Open
Keywords: catalysis; energy; plasma; surface interactions; mechanism; atmospheric plasma catalysis; plasma characterization; theory and modeling
(This special issue belongs to the Section Organic Chemistry)
Exploring the Nanomaterials in Electrochemical Sensor: From Design to Application
edited by Hongbo Li and
submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open
Keywords: nanomaterials; metal– organic frameworks; quantum dots; covalent– organic frameworks; polymers; organic– inorganic nanocomposites; electrochemical sensors
(This special issue belongs to the Section Materials Chemistry)
Sustainable Approaches to Nanoparticle Synthesis: Toward a Greener and Safer Future submission deadline 31 Dec 2025 | Viewed by 135 | Submission Open
Keywords: green synthesis of nanoparticles; sustainable nanotechnology; eco-friendly nanomaterials; biogenic nanoparticle synthesis; plant-mediated nanoparticle synthesis; microbial-assisted nanoparticle synthesis; renewable precursors in nanotechnology; low-toxicity nanomaterials; biological activities of green synthesized nanoparticles
(This special issue belongs to the Section Green Chemistry)
Advances in Material Chemistry for Sustainable Energy Storage: Innovations, Challenges, and Future Directions
edited by and Peng Liu
submission deadline 31 Dec 2025 | Viewed by 129 | Submission Open
Keywords: phase change thermal energy storage material; energy storage hydrogel materials; materials for photocatalytic hydrogen production; thermochemical heat storage materials; electrochemical energy storage material
(This special issue belongs to the Section Materials Chemistry)
Bioactive Secondary Metabolites in Natural Products submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open
Keywords: bioactive metabolites from mushrooms; medicinal plant metabolites; pro-health secondary metabolites from natural products; antiaging natural sources metabolites; natural dietary supplements
(This special issue belongs to the Section Natural Products Chemistry)
Chromatographic Analysis of Pesticide Residues in Environmental Samples
edited by
submission deadline 31 Dec 2025 | Viewed by 106 | Submission Open
Keywords: chromatography coupled to mass spectrometry; targeted analysis; non-targeted analysis; validation; plants; soils
(This special issue belongs to the Section Analytical Chemistry)
Metal Oxide Nanomaterials: Synthesis, Structures and Optical Properties
edited by
submission deadline 31 Dec 2025 | Viewed by 106 | Submission Open
Keywords: metal oxide; nanomaterial; synthesis; structure; optical; electric; property; application; catalyst; photodegradation; solar cell; sensor; vector; drug delivery; nanomedicine; green technology; optical communication; metal doping; photocatalysis; band-gap engineering; defect characterization and engineering; biosensor; antibacterial
(This special issue belongs to the Section Nanochemistry)
Photocatalytic Nanocomposites: Design, Mechanisms and Applications
edited by Ramona-Crina Suciu
submission deadline 31 Dec 2025 | Viewed by 95 | Submission Open
Keywords: photocatalytic; nanocomposites; matrix; reinforcement; nanomaterials
(This special issue belongs to the Section Nanochemistry)
Advanced Delivery Systems for Therapeutic and Agro-Chemical Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 92 | Submission Open
Keywords: micro- and nano-carriers; responsive; toxicology; safety; drug delivery
(This special issue belongs to the Section Applied Chemistry)
Advances in Environmental Remediation and Wind–Sand Stabilization Materials
edited by
submission deadline 31 Dec 2025 | Viewed by 77 | Submission Open
Keywords: soil remediation and improvement; water purification; windbreak and sand fixation; air purification materials; natural eco-materials
(This special issue belongs to the Section Applied Chemistry)
Emerging Technologies for Chemical Recovery of Spent Batteries
edited by Yuan Liang and
submission deadline 31 Dec 2025 | Viewed by 72 | Submission Open
Keywords: spent battery recycling; chemical recycling technologies; critical metal recovery; hydrometallurgy; bioleaching; circular economy
(This special issue belongs to the Section Green Chemistry)
Degradation of Soil Pollutants
edited by
submission deadline 31 Dec 2025 | Viewed by 68 | Submission Open
Keywords: degradation; remediation; analysis; pollutions; soil; new technology
(This special issue belongs to the Section Applied Chemistry)
Next-Generation Deep Eutectic Solvents for Sustainable Synthesis and Electrochemical Application
edited by
submission deadline 1 Jan 2026 | Viewed by 146 | Submission Open
Keywords: deep eutectic solvents; electrosynthesis; energy storage/conversion; chemical synthesis; wearable electronic devices; computation methods
(This special issue belongs to the Section Green Chemistry)
Advances in Amylases, 2nd Edition
edited by
submission deadline 15 Jan 2026 | Viewed by 412 | Submission Open
Keywords: enzyme; alpha-amylase enzyme; starch and glycogen; gut microbiome oriented study
(This special issue belongs to the Section Bioorganic Chemistry)
Review Papers in Materials Chemistry—2nd Edition submission deadline 15 Jan 2026 | Viewed by 209 | Submission Open
Keywords: materials chemistry; organic and inorganic materials; biomaterials; nanomaterials; hybrid materials; core-shell materials; thin films; self-assembling systems; tailored and unusual properties of materials
(This special issue belongs to the Section Materials Chemistry)
Transition Metal Complexes with Bioactive Ligands
edited by
submission deadline 16 Jan 2026 | 1 articles | Viewed by 1016 | Submission Open
Keywords: transition metal complexes; DFT; QTAIM; biological activity; bioactive ligands; crystal structures
(This special issue belongs to the Section Organometallic Chemistry)
Isolation, Analysis, and Biological Activities of Secondary Metabolites Derived from Plants
edited by , Mindaugas Liaudanskas and
submission deadline 20 Jan 2026 | 4 articles | Viewed by 6447 | Submission Open
Keywords: isolation; analysis; phytochemical composition; biological activity
(This special issue belongs to the Section Natural Products Chemistry)
Advanced Polymer Composites for Sustainable Technologies: Synthesis, Characterization, and Performance
edited by Fujuan Liu
submission deadline 20 Jan 2026 | 1 articles | Viewed by 913 | Submission Open
Keywords: sustainable polymer composites; thermal insulation materials; fiber-reinforced composites; renewable energy applications; biodegradable composites; flexible electronics; light-emitting materials; Janus membrane design; nanomaterials; biomimetic design
(This special issue belongs to the Section Macromolecular Chemistry)
Molecular, Technological and Nutritional Aspects of Food Fortification and Processing submission deadline 30 Jan 2026 | 1 articles | Viewed by 1660 | Submission Open
Keywords: food fortification and processing; molecular; technological; and nutritional aspects; food composition; functionality; nutritional quality
(This special issue belongs to the Section Food Chemistry)
The Application of LC-MS in Pharmaceutical Analysis—2nd Edition
edited by Wing Lam and
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1540 | Submission Open
Keywords: LC– MS; chemical characterization; metabolite identification; metabolomics; pharmacokinetics
(This special issue belongs to the Section Analytical Chemistry)
State of the Art of Natural Antioxidants: Extraction, Detection and Biofunctions—2nd Edition submission deadline 30 Jan 2026 | 1 articles | Viewed by 789 | Submission Open
Keywords: antioxidant; phytochemistry; bioactive molecules; biotechnology; biomolecules; analytical chemistry; food chemistry; phytomedicine
(This special issue belongs to the Section Natural Products Chemistry)
Phosphorus-Based Compounds in Medicinal Chemistry
edited by
submission deadline 30 Jan 2026 | Viewed by 258 | Submission Open
Keywords: phosphorus-containing drugs; prodrugs; phosphonates; phosphinates; bioisosteres; enzyme inhibitors; drug design; drug discovery
(This special issue belongs to the Section Medicinal Chemistry)
Phytochemicals as Promising Molecules in Acute and Chronic Neurodegeneration
edited by
submission deadline 30 Jan 2026 | Viewed by 176 | Submission Open
Keywords: phytochemicals; nutrients; morphology; transmission electron microscopy; autophagy; proteasome; neurodegeneration; central nervous system; peripheral nervous system; sensory organs
(This special issue belongs to the Section Natural Products Chemistry)
Advances in Nanoscale Drug Delivery Technologies and Theranostics
edited by and Valérie Maraval
submission deadline 30 Jan 2026 | Viewed by 112 | Submission Open
Keywords: drug delivery; theranostics; nanoparticles; dendrimers; nanovesicle; nanomicelles; polymers; nanomaterials
(This special issue belongs to the Section Nanochemistry)
Advanced Functional Quantum Dots: Design, Properties and Application submission deadline 30 Jan 2026 | Viewed by 75 | Submission Open
Keywords: quantum dots; functionalization; quantum modelling; novel materials; nanomaterials
(This special issue belongs to the Section Nanochemistry)
Health Benefits and Applications of Bioactive Phenolic Compounds submission deadline 31 Jan 2026 | 5 articles | Viewed by 19106 | Submission Open
Keywords: natural bioactive compounds; health benefits; bioactive properties; extraction methodologies; in vitro and in vivo studies; potential applications
(This special issue belongs to the Section Natural Products Chemistry)
Organosulfur and Organoselenium Chemistry II
edited by Ming Wang
submission deadline 31 Jan 2026 | 6 articles | Viewed by 18252 | Submission Open
Keywords: organosulfur; organoselenium; synthesis; transformation; application
(This special issue belongs to the Section Organic Chemistry)
Recent Advances in Natural Compounds Research: Chemistry, Biology and Biotechnology submission deadline 31 Jan 2026 | 6 articles | Viewed by 16737 | Submission Open
Keywords: bioactive constituents; phytoextract; biological activity
(This special issue belongs to the Section Natural Products Chemistry)
Design and Mechanisms of Photo(electro)catalysts for Water Splitting
edited by Zhaohui Zhou, Jiafeng Geng and
submission deadline 31 Jan 2026 | 3 articles | Viewed by 14052 | Submission Open
Keywords: photocatalysis; electrocatalysis; photoelectrocatalysis; photo(electro)catalysts synthesis; water splitting; hydrogen production; renewable fuels
(This special issue belongs to the Section Applied Chemistry)
Analytical Insights into Bioactive Compounds in Pharmaceutical Formulations
edited by
submission deadline 31 Jan 2026 | 5 articles | Viewed by 12965 | Submission Open
Keywords: bioactive compounds; drug quality control; new pharmaceutical formulations; advanced analytical techniques; falsified medicines; methodologies
(This special issue belongs to the Section Analytical Chemistry)
Applications of Fluorescent Sensors in Food and Environment submission deadline 31 Jan 2026 | 4 articles | Viewed by 10471 | Submission Open
Keywords: environmental pollutants; food quality; heavy metals and anions sensing; fluorescent quantum dots; luminescent metal organic frameworks (LMOFs); fluorescent polymers; fluorescent small molecules and supramolecular sensors; vapoluminescent materials
(This special issue belongs to the Section Materials Chemistry)
Innovative Anticancer Compounds and Therapeutic Strategies
edited by and Beata Marciniak
submission deadline 31 Jan 2026 | 6 articles | Viewed by 10277 | Submission Open
Keywords: chemical biology; cancer therapeutics; natural compounds; small molecule drug discovery; targeted therapy; high-throughput screening; structure-based drug design; translational research
(This special issue belongs to the Section Medicinal Chemistry)
Chemistry of Nucleosides and Nucleotides and Their Analogues submission deadline 31 Jan 2026 | 3 articles | Viewed by 10258 | Submission Open
Keywords: nucleosides; nucleotides; and nucleic acids; modified nucleosides and nucleotides; nucleoside and nucleotide analogues; antimetabolites; oligonucleotides; organic synthesis; bioorganic chemistry; medicinal chemistry
(This special issue belongs to the Section Organic Chemistry)
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