Special Issue "Protease and Carbonic Anhydrase Inhibitors, II"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2020).
Interests: drug design; metalloenzymes; carbonic anhydrases, anticancer agents; antiinfectives; sulfonamides; coumarins
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Interests: medicinal chemistry; drug design; computational chemistry; carbonic anhydrases; enzymatic evaluation
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Proteases and carbonic anhydrases are among the most widespread enzymes in organisms all over the phylogenetic tree, in which they play crucial physiological roles. Dysregulation of their activity is connected with many diseases, such as tumors, viral infections, blood coagulation disorders, digestive diseases, etc. Protease inhibitors targeting all classes of such known enzymes are widely used as antivirals (against HIV and hepatitis C infections), antithromodotics (targeting serine proteases involved in the blood coagulation cascade), whereas inhibitors of other proteases, such as matrix metalloproteinases, have found fewer applications due to their toxicity problems. Carbonic anhydrase inhibitors, on the other hand, are used as antiglaucoma, antiepileptic, antiobesity, and as diuretic drugs, whereas newer applications target metastatic tumors, both for treatment and imaging, with one small molecule and one antibody in advanced clinical trials. Antiinfectives, based on inhibition of carbonic anhydrases from pathogenic bacteria, fungi, and protozoa, have also begun to be investigated.
The present Special Issue of the International Journal of Molecular Sciences welcomes contributions dealing with all aspects connected to the chemistry, biochemistry, pharmacology and toxicology of this important class of enzyme inhibitors.
You may wish to check the previous volume.
Prof. Dr. Claudiu T. Supuran
Dr. Alessio Nocentini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- carbonic anhydrase
- antiviral drug
- antitumor drug
- drug design
- serine protease
- aspartic protease