Next Article in Journal
On Forgotten Topological Indices of Some Dendrimers Structure
Next Article in Special Issue
Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors
Previous Article in Journal
Biosynthesis of ZnO Nanoparticles by a New Pichia kudriavzevii Yeast Strain and Evaluation of Their Antimicrobial and Antioxidant Activities
Previous Article in Special Issue
Novel Sulfamethoxazole Ureas and Oxalamide as Potential Antimycobacterial Agents
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(6), 793;

Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors

Department of Chemistry, Faculty of Sciences, İstanbul Medeniyet University, 34730 İstanbul, Turkey
Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey
Department of Basic Science, Faculty of Science, Erzurum Technical University, 25240 Erzurum, Turkey
Pharmacy Services Program, Vocational School of Health Services, Artvin Coruh University, 08000 Artvin, Turkey
Department of Bioengineering, Faculty of Engineering and Architecture, Sinop University, 57000 Sinop, Turkey
Department of Molecular Biology and Genetics, Faculty of Sciences and Arts, Muş Alparslan University, 49250 Muş, Turkey
TUBITAK UME, Chemistry Group Laboratories, P.O. Box: 54, 41470 Gebze Kocaeli, Turkey
Department of Organic Chemistry, Faculty of Science, Istanbul Technical University, 34469 Istanbul, Turkey
Author to whom correspondence should be addressed.
Academic Editor: Claudiu T. Supuran
Received: 28 February 2017 / Revised: 27 April 2017 / Accepted: 9 May 2017 / Published: 24 May 2017
(This article belongs to the Special Issue Sulfonamides)
Full-Text   |   PDF [702 KB, uploaded 24 May 2017]   |  


Secondary sulfonamides (4a8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C., as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a8h) are effective LPO inhibitors. The Ki values of secondary sulfonamide derivatives (4a8h) were found in the range of 1.096 × 10−3 to 1203.83 µM against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with Ki values of 1.096 × 10−3 ± 0.471 × 10−3 µM as non-competitive inhibition. View Full-Text
Keywords: lactoperoxidase; secondary sulfonamide; enzyme purification; enzyme inhibition lactoperoxidase; secondary sulfonamide; enzyme purification; enzyme inhibition

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Köksal, Z.; Kalin, R.; Camadan, Y.; Usanmaz, H.; Almaz, Z.; Gülçin, İ.; Gokcen, T.; Gören, A.C.; Ozdemir, H. Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors. Molecules 2017, 22, 793.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top