Special Issue "Cancer Metabolomics 2016"
Deadline for manuscript submissions: closed (31 July 2016).
Interests: drug design; metalloenzymes; carbonic anhydrases, anticancer agents; antiinfectives; sulfonamides; coumarins
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Interests: Technological advances in NMR tissue metabolomics for cancer biomarkers; Technological advantages in MS biofluid metabolomics for cancer biomarkers; Metabolic Biomarkers for cancer detection; Metabolic Biomarkers for cancer treatment response; Non-invasive metabolic imaging (pre-clinical and clinical)
Metabolomics is an essential part of system biology, with the main focus on comprehensively analyzing endogenous small-molecules (metabolites) in cells, tissues, and body fluids. The analytical platforms comprise of NMR (nuclear magnetic resonance) and MS (mass spectrometry: LC-MS, GC-MS, ESI) technologies, followed by multivariate analyses on complex quantitative or semi-quantitative data sets (PCA, PLS-DA, neuronal networks). Since Warburg’s discovery of abnormal aerobic glycolysis in cancer cells, oncology logically represents a classic application area for basic and translational metabolomics efforts. Most recently, some individual metabolites have also became the major players in the truly clinical arena of cancer diagnostics: using in vivo metabolic imaging techniques, such as magnetic resonance spectroscopy (MRS) and positron emission tomography (PET), identified metabolic biomarkers are directly visualized in cancerous tissues without need of a biopsy. This Special Issue of Metabolites focuses on NMR- and MS-based preclinical and early clinical biomarker identification studies in various body fluids and tissue biopsies (aspirates); their translation into the “first-in-human” in vivo PET and MRS metabolic imaging will be discussed. The state-of-the-art “unconventional” technologies for metabolite identification and detection will also be briefly described. The main goals of this Special Issue are to provide all readers (independently of their technological level of expertise) with a comprehensive overview of cancer-related metabolic biomarkers and to summarize the most robust translational metabolomics protocols for future study designs.
Dr. Natalie Serkova
Prof. Dr. Claudiu T. Supuran
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- untargeted quantitative nmr metabolomics
- highly sensitive untargeted ms metabolomics
- targeted ms metabolomics approaches
- cancer-related metabolic biomarkers
- biomarker validation for clinical trials
- in vivo metabolic imaging