Editorial Board Members’ Collection Series: "Enzyme Inhibition"

Dear Colleagues,

The human genome only encodes for around 30,000 genes, which is one third of what was previously believed before the first genomes were cloned, and there has been still significant debate surrounding how many of them are druggable. Presently clinically used drugs act on around 400 of these targets pertaining to proteins, nucleic acids, and (more rarely) sugars or lipids, which belong to the human host or various pathogens (bacteria, fungi, protozoans, and other parasites). Around 50% of the known drug targets are enzymes; thus, enzyme inhibition (and, in some cases, activation) constitutes an important field of biomedical research and therapeutic intervention. The present Special Issue will address all research topics connected with enzymes, as well as their inhibition and activation, based on molecular biology, structural chemical biology, drug design, and pharmacological studies in the field. All enzyme classes will be considered as relevant proteins for such research topics, albeit with a preference for those connected to major biomedical problems, i.e., cancer, infectious diseases, drug resistance, obesity, as well as cardiovascular and central nervous system conditions.

Prof. Dr. Claudiu T. Supuran
Prof. Dr. Piotr Paneth
Guest Editors

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