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30th Anniversary of IJMS: Updates and Advances in Biochemistry
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30th Anniversary of IJMS: Updates and Advances in Biochemistry

A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Biochemistry".

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Editor

Prof. Dr. Claudiu T. Supuran

grade E-Mail Website
Guest Editor
NEUROFARBA Department, Sezione di Scienze Farmaceutiche, University of Florence, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, FI, Italy
Interests: drug design; metalloenzymes; carbonic anhydrases; anticancer agents; antiinfectives; sulfonamides; coumarins
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

The collection of papers present in this anniversary issue of IJMS features some of the most interesting developments in the biochemistry field over the last decades. The huge progress made in genetics and cloning of genomes of many organisms, connected with the latest developments in structural biology and other biophysical techniques, made it possible to understand the structure and functions of many biological molecules involved in all life processes, from structural and catalytic proteins, to nucleic acids, as well as protein–protein and protein–nucleic acid complexes. This is crucial for designing tools to interfere with their function and many such molecules may become drugs or diagnostic tools. Although many of these phenomena are not yet completely understood, the significant progress that has been made is partly due to some of the crucial papers published in the bets biochemical journals, among which IJMS has strongly emerged. With the aim of stimulating a broad interest in this topic, I strongly urge scientists active in the field to read this interesting issue of the journal.

Prof. Dr. Claudiu T. Supuran
Guest Editor

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Keywords

  • proteins
  • enzymes
  • nucleic acids
  • signal transduction
  • receptors
  • enzyme inhibition
  • drug design
  • anticancer drugs
  • antiinfectives
  • drug resistance
  • antiobesity agents
  • molecular mechanism of drugs
  • molecular pathways to pathogenesis
  • protein degradation
  • PROTACs

Published Papers (1 paper)

2025

29 pages, 4978 KiB  
Article
HPLC-DAD-ESI/MS and 2D-TLC Analyses of Secondary Metabolites from Selected Poplar Leaves and an Evaluation of Their Antioxidant Potential
by Loretta Pobłocka-Olech, Mirosława Krauze-Baranowska, Sylwia Godlewska and Katarzyna Kimel
Int. J. Mol. Sci. 2025, 26(13), 6189; https://doi.org/10.3390/ijms26136189 - 27 Jun 2025
Viewed by 324
Abstract
Poplar leaves (Populi folium) are a herbal remedy traditionally used for the treatment of rheumatic diseases and prostate inflammation. The aim of our study was a comprehensive identification of secondary metabolites occurring in the leaves of Populus alba, Populus × [...] Read more.
Poplar leaves (Populi folium) are a herbal remedy traditionally used for the treatment of rheumatic diseases and prostate inflammation. The aim of our study was a comprehensive identification of secondary metabolites occurring in the leaves of Populus alba, Populus × candicans, and Populus nigra, in order to search for a source of raw plant material rich in active compounds. Total salicylate (TSC), flavonoid (TFC), and phenolic compound (TPC) contents were determined, and the antioxidant potential was assessed using DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline- 6-sulfonic acid) diammonium salt), and FRAP (ferric reducing antioxidant power) assays as well as 2D-TLC (two-dimensional thin layer chromatography) bioautography using DPPH, riboflavin-light-NBT (nitro blue tetrazolium chloride), and xanthine oxidase inhibition tests. Secondary metabolites present in the analyzed poplar leaves were identified under the developed HPLC-DAD-ESI/MS (high performance liquid chromatography with photodiode array detection and electrospray ionization mass spectrometric detection analysis conditions and using the 2D-TLC method. Among the 80 identified compounds, 13 were shown for the first time in the genus Populus. The most diverse and similar set of flavonoids characterized the leaves of P. × candicans and P. nigra, while numerous salicylic compounds were present in the leaves of P. alba and P. × candicans. All analyzed leaves are a rich source of phenolic compounds. The highest flavonoid content was found in the leaves of P. × candicans and P. nigra, while the leaves of P. alba were characterized by the highest content of salicylates. All examined poplar leaves demonstrated antioxidant potential in all the assays used, which decreased in the following order: P. nigra, P. × candicans, P. alba. Full article
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