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Molecules 2017, 22(3), 434;

N-Pyrrylarylsulfones with High Therapeutic Potential

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia—Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Roma, Italy
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fiscano, Salerno, Italy
Author to whom correspondence should be addressed.
Academic Editor: Claudiu T. Supuran
Received: 12 February 2017 / Revised: 1 March 2017 / Accepted: 3 March 2017 / Published: 9 March 2017
(This article belongs to the Special Issue Sulfonamides)
Full-Text   |   PDF [3222 KB, uploaded 9 March 2017]   |  


This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents. View Full-Text
Keywords: sulfonamide; heterocycle; polycyclic compound; therapeutic agent sulfonamide; heterocycle; polycyclic compound; therapeutic agent

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Famiglini, V.; Castellano, S.; Silvestri, R. N-Pyrrylarylsulfones with High Therapeutic Potential. Molecules 2017, 22, 434.

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