Special Issue "Protein Modifications and Bioconjugation"
Deadline for manuscript submissions: closed (15 December 2017)
Prof. Zhaohui Sunny Zhou
Department of Chemistry and Chemical Biology, Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA 02115-5000, USA
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Interests: protein chemistry, protein modifications, bioconjugation, protein pharmaceuticals, biotechnology, mass spectrometry, bioanalysis, bioorganic chemistry and enzymology
Professor Litai Jin
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325000, China
You are cordially invited to contribute to a Special Issue of “Protein Modifications and Bioconjugation”. Since structures determine functions, modifications of proteins modulate their functions, and, thus, play diverse and crucial roles in chemistry, biology, medicine and engineering. For example, various post-translational modifications (PTM’s) are essential key players in gene regulation and disease development, and many of the enzymes involved (e.g., methyltransferases, kinases and deacetylases) have been actively pursued as drug targets. Pertinent to PTMs, a battery of selective derivatization methods has been developed to label or tag modified amino acids, thereby permitting facile detection and affinity enrichment. From an engineering point of view, bioconjugation introduces new functions to proteins. For therapeutic applications, PEGylation has widely employed to enhance circulation half-lives, to reduce immunogenicity and to shield from proteolysis. Recently, antibody-drug conjugates (ADCs) have introduced new opportunities for battling diseases that were not possible with either antibodies or drugs alone. With the advent of many site-specific bioconjugation techniques, hybrid modality engineering of peptides and proteins represents a promising fertile frontier in the next-generation of materials and medicine.
All aspects of the topics are welcome, including both method developments and novel discoveries. Topics include but limited to bioconjugation of peptides and proteins, protein synthesis, post-translational modifications (PTMs), unnatural amino acids, peptide and protein pharmaceuticals (e.g., antibody-drug conjugates and hybrid modality engineering), functional probes and proteomics (e.g., activity-based protein profiling), specific chemo-enzymatic tagging and affinity labeling, and protein analysis (e.g., mass spectrometry) that involve chemical derivatization. Both original report and review are accepted.
Prof. Dr. Zhaohui Sunny Zhou
Prof. Dr. Litai Jin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.