Special Issue "Site-Selective Modification of Biomolecules"
Deadline for manuscript submissions: 31 July 2019
Prof. Dr. Steven Verhelst
1. Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Belgium
2. AG Chemical Proteomics, Leibniz Institute for Analytical Sciences ISAS, Dortmund, Germany
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Interests: activity-based probes; activity-based protein profiling; bioorthogonal chemistry; chemical proteomics; cleavable linkers; intramembrane proteases; photoaffinity labeling; proteases; protease inhibitors
The site-specific modification of biomolecules plays a central role in chemical biology, helping elucidate definite functions within a complex network of interactions. Furthermore, it has been employed to improve the biological activity and stability of peptides, proteins, carbohydrates, and oligonucleotides. The development of synthetic methodologies and the application of covalent chemical probes are crucial to support these studies. Site-specific labeling can take place on the purified biomolecule, within a cell extract, or even in vivo. Modifications can be introduced via various mechanisms, including bioorthogonal chemistry, (re-)activity-based probes, which utilize electrophiles that modify nucleophiles in, e.g., enzymes, photoaffinity labeling, which makes use of tight-binding inhibitors in combination with a photocrosslinker, metabolic labeling, which utilizes the endogenous metabolic machinery of the cell to introduce site-selective modifications, and site-selective catalysis. This Special Issue aims to draw an overview of the chemical development of the different strategies and their implementation in biological applications.
Prof. Dr. Steven Verhelst
Dr. Martin Witte
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- activity-based protein profiling
- bioorthogonal chemistry
- click chemistry
- covalent chemical probes
- protein labeling
- photoaffinity labeling
- carbohydrate modification
- oligonucleotide labeling