Curcumin an Example of Pleiotropic Agents—Design, Synthesis and Biological Evaluation of Curcumin Analogues or Curcumin Derivatives

Dear Colleagues,

Curcumin is a natural phytochemical obtained from the dried root and rhizome of Turmeric (Curcuma Longa). It is a pleiotropic agent, showing interference with multiple cell signaling pathways, including apoptosis, proliferation (HER-2, EGFR, and AP-1), angiogenesis (VEGF), and inflammation (NF-κB, TNF, IL-6, IL-1, COX-2, and 5-LOX). In the last decade, various synthetic analogues have been prepared and evaluated for pleiotropic therapeutic  applications.

Our target within this Special Issue will be to highlight contemporary research considering the design (in silico) synthesis and biological activities (evaluation and critical discussion), as well as reviews referring to the pleiotropic activities of curcuminoids, curcumin derivatives and curcumin analogues.

Additionally, we would like to have as many cases of multitaget applications of the above chemical structures in order to point out the importance of this chemical structure

Prof. Dr. D. Hadjipavlou-Litina
Guest Editor

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