Synthesis, Properties and Application of Five- and Six-Membered Heterocycles
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 9
Special Issue Editors
Interests: heterocyclic compound; cyclization; ring opening reaction; carbazole; medicinal chemistry; michael addition
Interests: heteroaromatic synthesis; organometallic nanohybrids; nitroderivatives; ring-opening and ring-closing reactions; computational chemistry; medicinal chemistry
Special Issue Information
Dear Colleagues,
The rational design, efficient synthesis, and comprehensive characterization of five- and six-membered heterocyclic compounds represent essential components of modern organic and medicinal chemistry research. The enduring scientific interest in these privileged structural motifs arises from their widespread presence in bioactive natural products, pharmaceuticals, and advanced functional materials. These heterocyclic systems act as critical pharmacophores in drug discovery, demonstrating a broad spectrum of biological activities, including antimicrobial, anticancer, anti-inflammatory, and neurotropic effects. Additionally, five- and six-membered heterocycles exhibit remarkable utility in materials science, playing a significant role in organic electronics, photovoltaic devices, and luminescent materials.
This Special Issue aims to present cutting-edge research highlighting the latest advancements in the chemistry of five- and six-membered heterocyclic compounds, either isolated or benzofused. We invite researchers to contribute original research articles, concise communications, and comprehensive reviews covering, but not limited to, the following key areas:
- Synthetic Methodologies: Development of novel and efficient synthetic strategies for five- and six-membered heterocycles, including transition-metal catalysis, multicomponent and cascade reactions, and green chemistry approaches.
- Structural Elucidation and Computational Studies: Advanced spectroscopic methods for characterization, complemented by computational studies such as density functional theory (DFT) calculations, molecular dynamics simulations, and quantum chemical analyses to explore reaction mechanisms and structure-property relationships.
- Pharmacological Investigations: Exploration of structure–activity relationships (SAR), biological evaluation, and innovative pharmacological applications.
- Materials Science Applications: Design, synthesis, and characterization of heterocycle-based materials for optoelectronic, photonic, and sensing applications.
- Comprehensive Reviews: analyses offering critical assessments of recent progress and future trends in the synthesis, characterization, and application of five- and six-membered heterocyclic compounds.
Dr. Lara Bianchi
Prof. Dr. Massimo Maccagno
Guest Editors
Manuscript Submission Information
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Keywords
- heterocycle synthesis
- transition-metal catalysis
- multicomponent reactions
- structural characterization
- computational chemistry
- pharmacological activity
- functional materials
- benzofused heterocycles
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