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Special Issue "Natural Products for Neurodegenerative Diseases"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2019

Special Issue Editor

Guest Editor
Prof. Dr. Eduardo Sobarzo-Sánchez

Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Spain, and Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Chile
Website | E-Mail
Phone: +34 8818 14887
Fax: +34 981 59 49 12
Interests: medicinal chemistry; natural products; photochemistry reactivity; aporphine and oxoaporphine; oxoisoaporphine; coumarins

Special Issue Information

Dear Colleagues,

In antiquity, diverse natural compounds were used to treat several ailments and chronic diseases and were recognized for their therapeutic properties in folklore medicine. These compounds have heterogeneous chemical structure and varied pharmacological activity, being useful in the treatment of diseases of high complexity such as Parkinson’s disease, Alzheimer's disease, and others. Notwithstanding, at the present time, commercial drugs are in many cases aspecific and present side effects that increase pain or malaise in patients. It has been observed that some chemical structures, such as quinone, are present in many compounds and are associated with successful medical treatment. Thus, extended carbon systems with planar moieties that favor their intercalation among aminoacid residues and specific receptors of certain pathogens seem to be key to generating effective drugs. Many researchers are studying how to incorporate quinone moieties in complex chemical structures by large-scale organic synthesis; at the same time, they are interested in discovering new natural products with effective medical applications. The interest in these drugs is especially related to the treatment of the so-called chronic diseases, which include allergies, neurodegenerative disorders like Alzheimer's disease, asthma, cancer, diabetes, epilepsy, heart disease, etc..

Therefore, the aim of this Special Issue, is to collect diverse research articles and reviews describing the possible and future therapeutic applications of compounds or commercial medicines, as well as their synthesis and isolation (if natural products); of interest are also theoretical studies of structure–activity relationships of heterocycle and hydrocarbon compounds that incorporate active fragments/moieties of natural products and are being tested for their possible application in the treatment of chronic diseases. The critical and objective perspective offered by these contributions will help us to appreciate and emphasize the latest advances in the field of organic and medicinal chemistry.

Prof. Dr. Eduardo Sobarzo-Sánchez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chronic disease
  • Natural products
  • Neurodegenerative diseases
  • Antinociceptive drug
  • Drug delivery system

Published Papers (2 papers)

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Research

Open AccessArticle
Assessment of Antidepressant Effect of the Aerial Parts of Micromeria myrtifolia Boiss. & Hohen on Mice
Molecules 2019, 24(10), 1869; https://doi.org/10.3390/molecules24101869
Received: 10 April 2019 / Revised: 8 May 2019 / Accepted: 14 May 2019 / Published: 15 May 2019
PDF Full-text (659 KB) | HTML Full-text | XML Full-text
Abstract
The currently available antidepressant agents necessitate the development of newer alternatives because of their serious adverse effects and costs. Traditional medicinal knowledge is likely the key that opens the door to discover new medicines. In Turkish folk medicine, the infusion prepared from aerial [...] Read more.
The currently available antidepressant agents necessitate the development of newer alternatives because of their serious adverse effects and costs. Traditional medicinal knowledge is likely the key that opens the door to discover new medicines. In Turkish folk medicine, the infusion prepared from aerial parts of Micromeria myrtifolia Boiss. & Hohen is used as pleasure and medicinal tea for its relaxing action. The present research was conceived to confirm the antidepressant’s potential of this traditional medicinal plant. In this process, first of all, the collected and shade-dried aerial parts of M. myrtifolia were powdered and then, extracted using solvents with different polarity as follows; n-hexane, ethyl acetate (EtOAc), and methanol (MeOH). The antidepressant activity of the extracts was evaluated by using several in vivo and in vitro experimental models of depression. When the data obtained from the control and experimental groups were compared, it was determined that the MeOH extract was the most active. The active components of this extract were isolated and identified utilizing various chromatographic separation techniques. The MeOH extract was applied to reversed phase (RP-18) column chromatography to obtain five main fractions and they were tested on antidepressant activity models. The isolated compounds from the obtained fractions were elucidated as rosmarinic acid (1), myricetin (2), apigenin (3), and naringenin (4) which were assumed to be responsible for the antidepressant activity of the aerial parts. According to the results, rosmarinic acid, myricetin, apigenin, and naringenin showed statistically significant activity on forced swimming test and tetrabenazine-induced ptosis models, whereas only rosmarinic acid showed statistically significant activity on the tail suspension test. Apigenin displayed the highest inhibitory activity on MAO A and B enzymes. Studies in the future should be performed to investigate the antidepressant activity mechanism of these natural compounds. The current research could be an important step in the development of the new agents that can be used in the treatment of depression. Full article
(This article belongs to the Special Issue Natural Products for Neurodegenerative Diseases)
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Open AccessArticle
Systems Pharmacological Approach to Investigate the Mechanism of Ohwia caudata for Application to Alzheimer’s Disease
Molecules 2019, 24(8), 1499; https://doi.org/10.3390/molecules24081499
Received: 15 March 2019 / Revised: 5 April 2019 / Accepted: 13 April 2019 / Published: 17 April 2019
PDF Full-text (6565 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Ohwia caudata (OC)—a traditional Chinese medicine (TCM)—has been reported to have large numbers of flavonoids, alkaloids, and triterpenoids. The previous studies on OC for treating Alzheimer’s disease (AD) only focused on single targets and its mechanisms, while no report had shown about the [...] Read more.
Ohwia caudata (OC)—a traditional Chinese medicine (TCM)—has been reported to have large numbers of flavonoids, alkaloids, and triterpenoids. The previous studies on OC for treating Alzheimer’s disease (AD) only focused on single targets and its mechanisms, while no report had shown about the synergistic mechanism of the constituents from OC related to their potential treatment on dementia in any database. This study aimed to predict the bioactive targets constituents and find potential compounds from OC with better oral bioavailability and blood–brain barrier permeability against AD, by using a system network level-based in silico approach. The results revealed that two new flavonoids, and another 26 compounds isolated from OC in our lab, were highly connected to AD-related signaling pathways and biological processes, which were confirmed by compound–target network, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, respectively. Predicted by the virtual screening and various network pharmacology methods, we found the multiple mechanisms of OC, which are effective for alleviating AD symptoms through multiple targets in a synergetic way. Full article
(This article belongs to the Special Issue Natural Products for Neurodegenerative Diseases)
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Graphical abstract

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