Special Issue "Natural Products for Neurodegenerative Diseases"
Deadline for manuscript submissions: closed (31 July 2020).
2. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, Spain
Interests: medicinal chemistry; natural products; photochemistry reactivity; aporphine and oxoaporphine; oxoisoaporphine; coumarins
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In antiquity, diverse natural compounds were used to treat several ailments and chronic diseases and were recognized for their therapeutic properties in folklore medicine. These compounds have heterogeneous chemical structure and varied pharmacological activity, being useful in the treatment of diseases of high complexity such as Parkinson’s disease, Alzheimer's disease, and others. Notwithstanding, at the present time, commercial drugs are in many cases aspecific and present side effects that increase pain or malaise in patients. It has been observed that some chemical structures, such as quinone, are present in many compounds and are associated with successful medical treatment. Thus, extended carbon systems with planar moieties that favor their intercalation among aminoacid residues and specific receptors of certain pathogens seem to be key to generating effective drugs. Many researchers are studying how to incorporate quinone moieties in complex chemical structures by large-scale organic synthesis; at the same time, they are interested in discovering new natural products with effective medical applications. The interest in these drugs is especially related to the treatment of the so-called chronic diseases, which include allergies, neurodegenerative disorders like Alzheimer's disease, asthma, cancer, diabetes, epilepsy, heart disease, etc..
Therefore, the aim of this Special Issue, is to collect diverse research articles and reviews describing the possible and future therapeutic applications of compounds or commercial medicines, as well as their synthesis and isolation (if natural products); of interest are also theoretical studies of structure–activity relationships of heterocycle and hydrocarbon compounds that incorporate active fragments/moieties of natural products and are being tested for their possible application in the treatment of chronic diseases. The critical and objective perspective offered by these contributions will help us to appreciate and emphasize the latest advances in the field of organic and medicinal chemistry.
Prof. Dr. Eduardo Sobarzo-Sánchez
Manuscript Submission Information
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- Chronic disease
- Natural products
- Neurodegenerative diseases
- Antinociceptive drug
- Drug delivery system