Modulators of Histone Methylation: A Medicinal Chemistry Perspective

Dear Colleagues,

Epigenetics include all chromatin modifications occurring on both histones and DNA without affecting gene sequence (genetic). Several proteins are involved in these processes, and have been grouped into writers (i.e., HAT and HMT), readers (bromodomain and cromodomain) and erasers (HDAC, KDM), which play an important and precise role in controlling gene expression and cell functions. Histone methyl transferases, demethylases, as well as methyl readers, represent innovative and modern targets to develop potential new drugs useful for future treatment of several diseases, including cancer, metabolic disorders, inflammation and neurodegeneration.

This Special Issue aims to highlight recent research efforts on the medicinal chemistry approaches on histone methylation modulators and pointing a special attention to innovative medicinal chemistry and chemical biology recently applied to identifying new ligands as new potent and selective epigenetic modulators and their therapeutic potential.

We welcome original articles and short communications, as well as a limited number of review articles, on novel modulators of protein targets involved in histone methylation. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Dr. Sergio Valente

Guest Editors

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