Special Issue "Modulators of Histone Methylation: A Medicinal Chemistry Perspective"
Deadline for manuscript submissions: closed (1 June 2018)
Prof. Rino Ragno
Rome Center for Molecular Design, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P. le A. Moro 5, 00185 Roma, Italy
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Interests: design and synthesis of bioactive compounds; development of new 3-D QSAR procedures and their application in drug design; molecular docking in drug design; extraction of bioactive compounds from natural sources
Epigenetics include all chromatin modifications occurring on both histones and DNA without affecting gene sequence (genetic). Several proteins are involved in these processes, and have been grouped into writers (i.e., HAT and HMT), readers (bromodomain and cromodomain) and erasers (HDAC, KDM), which play an important and precise role in controlling gene expression and cell functions. Histone methyl transferases, demethylases, as well as methyl readers, represent innovative and modern targets to develop potential new drugs useful for future treatment of several diseases, including cancer, metabolic disorders, inflammation and neurodegeneration.
This Special Issue aims to highlight recent research efforts on the medicinal chemistry approaches on histone methylation modulators and pointing a special attention to innovative medicinal chemistry and chemical biology recently applied to identifying new ligands as new potent and selective epigenetic modulators and their therapeutic potential.
We welcome original articles and short communications, as well as a limited number of review articles, on novel modulators of protein targets involved in histone methylation. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.Dr. Sergio Valente
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- chromatin modifiers