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Special Issue "Recent Advances of G-Quadruplexes In Vivo and In Vitro"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 December 2019

Special Issue Editor

Guest Editor
Dr. Ta-Chau Chang

Institute of Atomic and Molecular Sciences&Genomics Research Center, Academia Sinica, Taipei 10617, Taiwan
Website | E-Mail
Interests: spectroscopy and microscopy; small molecules in cancer research; G-quadruplex structures

Special Issue Information

Dear Colleagues,

G-quadruplex (G4) structures formed by the stacking of G-quartets with the Hoogsteen hydrogen bonding of four guanines under physiological conditions have recently gained much attention as possible targets for human cancer. Accumulating evidence on the biological functions of G4 structures in regulating multiple cellular processes support the existence of G4 structures in vivo. Recently, imaging-based studies on G4 antibodies and G4 ligands for visualizing the presence of G4s in cells showed more G4 formations in cancer cells than in normal cells. These findings lay the foundation for further studies about the details of G4 formation, and give deeper insight into G4 functions in vivo for a better understanding of the G4 structural biology at a molecular level. Another challenge in G4 research is structural determination. Given that the structural properties of G4s are critical for designing the theranostic G4 ligands for human cancer, many questions on structural variation as a result of sequence deviation are yet to be addressed. For example, different loop and flanking nucleotides in G-rich sequences may cause dramatic differences in G4 structures, even in vitro. In addition, the structural diversity and polymorphism of some G-rich sequences could pose more challenges for the structural analysis. More studies of the thermal stability and kinetic competition, as well as the folding and unfolding pathways of G4s may provide more comprehensive elucidation on such questions and challenges. The translation of G4 knowledge from in vitro to in vivo is currently a cutting-edge research in G4s. This Special Issue covers all aspects of the recent advances of G4 research, including sequence variation for G4 formations, G4 structures, G4 functions, G4 biology, G4 ligands, G4 specific antibodies, and, particularly, the development of methods and techniques for G4 research.

Dr. Ta-Chau Chang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Sequence variation and G4 structure
  • Structural diversity and polymorphism
  • Folding dynamics of G4s
  • G4 biological functions
  • G4 ligands and G4 antibodies
  • Methods for structure determination
  • Techniques for monitoring G4 structures in cells

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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