Trends in Yeast Biochemistry and Biotechnology

A topical collection in Microorganisms (ISSN 2076-2607). This collection belongs to the section "Microbial Biotechnology".

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Editors


E-Mail Website
Collection Editor
Laboratory of Natural Science, Faculty of Economics, Toyo University, Hakusan Bunkyo-ku, Tokyo 112-8606, Japan
Interests: S. cerevisiae; C. albicans; vaccines; proteomics; inflammation; cell surface; yeast biotechnology; fermentation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Collection Editor
Office of Society-Academia Collaboration for Innovation (SACI), Kyoto University, Yoshidahonmachi, Sakyo-ku, Kyoto 606-8501, Japan
Interests: cell surface engineering; yeast engineering; yeast genome editing; yeast organelle engineering; yeast cell whole catalyst
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

This Topic Collection is a continuation of our previous Special Issue: “Trends in Yeast Biochemistry and Biotechnology”.

At present, yeasts are indispensable microorganisms for studies in biochemistry and biotechnology. Yeasts are important microorganisms not only as a eukaryote model in basic biology but also as a powerful producer of recombinant proteins and physiologically active compounds in the pharmaceutical industry. Furthermore, basic and applied research using yeasts are connected to each other, and the significance of knowledge exchange between both research fields is receiving attention. To open a door to future yeast biochemistry and biotechnology, we hope that researchers using yeasts in their studies will submit a research paper or review article to this Topic Collection.

Prof. Dr. Seiji Shibasaki
Prof. Dr. Mitsuyoshi Ueda
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • yeast
  • S. cerevisiae
  • C. albicans
  • yeast engineering

Related Special Issue

Published Papers (1 paper)

2025

12 pages, 1348 KiB  
Article
Role of Saccharomyces cerevisiae Fcy Proteins and Their Homologs in the Catabolism of Modified Heterocyclic Pyrimidine Bases
by Jaunius Urbonavičius, Iglė Vepštaitė-Monstavičė, Juliana Lukša-Žebelovič, Elena Servienė and Daiva Tauraitė
Microorganisms 2025, 13(7), 1506; https://doi.org/10.3390/microorganisms13071506 - 27 Jun 2025
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Abstract
The synthesis of various heterocyclic base modifications of nucleic acids has been thoroughly investigated; however, much less is known about their catabolism. Also, little is known about the transport of such compounds across the microbial cell membranes. Using the Saccharomyces cerevisiae single-gene deletion [...] Read more.
The synthesis of various heterocyclic base modifications of nucleic acids has been thoroughly investigated; however, much less is known about their catabolism. Also, little is known about the transport of such compounds across the microbial cell membranes. Using the Saccharomyces cerevisiae single-gene deletion library, we performed genome-wide screening for genes affecting the growth of yeast in minimal media supplemented with N4-acetylcytosine as a source of uracil. We found that Fcy1, Fcy21, Bud16, Gnd1, and Fur4 proteins are required for efficient growth in the tested medium. Additionally, we used several heterocyclic pyrimidine bases and Fcy homolog mutants to test their growth in respective minimal media. We found that tested permeases differently affect the growth of yeast that is dependent on the heterocyclic pyrimidine bases used as a source of uracil. The most pronounced effect was observed for the ∆fur4 mutant, which was growing much slower than the corresponding wild-type strain in the media supplemented with N4-acetylcytosine, 4-methylthiouracil, N4-methylcytosine, N4,N4-dimethylcytosine, 2-thiouracil, or 4-thiouracil. We suggest that Fur4 protein is the major yeast transporter of modified heterocyclic pyrimidine bases. Our observations might be helpful when investigating the actions of various heterocyclic base-based antifungal, anticancer, and antiviral drugs. Full article
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