Special Issue "Tularemia: Pathogenesis, Diagnostic, Prevention, and Treatment"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: Francisella; Legionella; pathogenesis; microbe-host interaction
Tularemia is a zoonosis caused by Francisella tularensis, a Gram-negative, facultative intracellular bacterium. Renewed medical and scientific interest for this pathogen has arisen since the 2000s, owing to its classification by the Center for Diseases Control and Prevention (USA) among the list of biological threat agents. Since then, outstanding research has been done, leading to significant discoveries in different fields, including taxonomy, phylogeny, phylogeography, epidemiology, and virulence mechanisms of F. tularensis, as well as the pathogenesis of tularemia. The most significant findings have arisen from genomic studies after hundreds of F. tularensis genomes were made available to the scientific community. The development of innovative genetic techniques has also made it possible to deepen knowledge in the field of virulence of Francisella tularensis. From a medical point of view, the extension of the tularemia endemic zone (especially in the southern hemisphere) and the description of new clinical manifestations of the disease are the most striking facts. Tularemia diagnostic methods have been diversified, improved, and better evaluated for their reliability in real clinical situations. Although therapeutic recommendations concerning tularemia are available, therapeutic failures and relapses remain frequent, demonstrating that the optimum treatment for the various forms of the disease remains to be defined.
The purpose of this topic is to provide an overall update on the medical and scientific knowledge concerning tularemia pathogenesis, diagnostic, prevention, and treatment. Current advances on the following aspects will be taken into account: clinical aspects, clinical microbiology, clinical pathology, histopathology, cell biology, systems biology, genetics, genomics, and metabolomics. The Guest-Editors of this Research Topic welcome original research articles and reviews on F. tularensis and tularemia that may include (but not limited to) the following aspects:
- tularemia pathogenesis, including cell and animal models, clinical pathology, and genetics
- tularemia diagnosis, prognosis, prevention, and treatment
Prof. Dr. Max Maurin
Prof. Dr. Marina Santic
Manuscript Submission Information
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