Dear Colleagues,

The evolution of multi-drug resistance organisms in the world and the difficulty of controlling the phenomenon must lead us to consider, evaluate, and propose alternatives to the infection control measures.

Most of the proposed control policies are based on a search for new strategies and recommendations to contact isolated patients who are identified as carriers or infected with MDRO. The recent pandemic related to COVID-19 has shown the limits of these policies and leads us to initiate a debate on new ways and means of prevention.

In this issue, we propose to address important questions that would allow us to consider MDRO control in our hospitals differently, such as:

• What are the lessons to be drawn from the COVID-19 pandemic and the spread of MDRO?
• Are MDRO organisms the same or different in terms of risk?
• Are contact isolations mandatory to control the spread of MDRO?
• Are adverse events related to contact isolation?
• What is the role of microbiota in acquisition and clearance of MDRO?
• Is it necessary to control the risk related to the environment? If so, when and how?
• Is decolonisation useful? When? For what organisms? How?

Prof. Dr. Jean-Ralph Zahar
Guest Editor

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