Focus on Pediatric Infectious Diseases

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 1951

Special Issue Editor


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Guest Editor
Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, 60-572 Poznań, Poland
Interests: infectious diseases; children

Special Issue Information

Dear Colleagues,

Historically, infectious diseases have been the leading cause of death among children, adolescents, and individuals with immune system dysfunctions for many centuries. It was only with recent scientific advancements, including the development of new antibiotics, vaccines, and increased awareness of epidemiology, that significant improvements in the prevention and treatment of numerous infections were achieved. As a result of these efforts, a false sense of security has emerged, leading to the marginalization of the significance of pediatric infectious diseases.

However, recent years have shown a resurgence in the incidence of infectious diseases in children. Environmental and climatic changes, significant human migration, and anti-vaccination movements have led to an increase in the number of patients with both well-known and newly emerging infections in various regions. At the same time, the emergence of new diagnostic methods, particularly molecular-based tests and the widespread availability of "rapid antigen tests," has enabled early detection of infectious diseases in children. Long-term monitoring and immunological studies provide valuable insights into the role of pathogens in the development of autoimmune processes.

These developments highlight the need for continuous exploration of new therapeutic approaches against infectious diseases, based on pharmacology, immunology, and the utilization of the child's own defense mechanisms. We invite submissions of articles on these pressing issues, contributing to the ongoing advancement of pediatric health and the fight against infectious diseases.

We look forward to receiving your contributions.

Dr. Katarzyna Mazur-Melewska
Guest Editor

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Keywords

  • pediatric
  • infectious diseases
  • viral infection
  • bacterial infection
  • parasites
  • therapy
  • epidemiology
  • immunization

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Published Papers (1 paper)

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Research

14 pages, 992 KiB  
Article
Increased Measured GFR and Proteinuria in Children with Previous Infection by SARS-CoV-2: Should We Be Concerned?
by Alessia Marcellino, Silvia Bloise, Carmelo Pirone, Giulia Brandino, Antonio Barberi, Emanuela Del Giudice, Vanessa Martucci, Mariateresa Sanseviero, Flavia Ventriglia and Riccardo Lubrano
Microorganisms 2025, 13(5), 1008; https://doi.org/10.3390/microorganisms13051008 - 27 Apr 2025
Viewed by 990
Abstract
Over the past 3 years, several kidney complications in children with severe involvement by SARS-CoV-2 have been described. However, literature data are still lacking regarding possible kidney injury in children with paucisymptomatic SARS-CoV-2 infection. Thus, we retrospectively evaluated renal function in those patients. [...] Read more.
Over the past 3 years, several kidney complications in children with severe involvement by SARS-CoV-2 have been described. However, literature data are still lacking regarding possible kidney injury in children with paucisymptomatic SARS-CoV-2 infection. Thus, we retrospectively evaluated renal function in those patients. Children between 3 and 18 years, without any renal disease, with previous paucisymptomatic SARS-CoV-2 infection from May 2020 to March 2022, were recruited at our post-COVID-19 outpatient clinic. We retrospectively collected: Glomerular filtration rate, Fractional-excretion-of-sodium (FENa), tubular-reabsorption-of-phosphate (TRP), calcium-creatinine-urine ratio (CaU/CrU); proteinuria/m2/day and microhematuria by urine cytofluorometry. A total of 148 children were enrolled after a median period of 3 (IQR 6) months after infection. Twenty-six patients (17.6%) had reduced GFR, fifty (33.9%) had hyperfiltration, eleven (7.4%) had abnormal FENa and/or TRP, twenty-two (14.9%) had hypercalciuria, seventy-eight (52.7%) had pathological daily proteinuria. Microhematuria was found in sixteen (10.9%) subjects. Hyperfiltration was more prevalent among males (38.9% vs. 22.4%, p = 0.027); CaU/CrU [median 0.08 (IQR 0.09) vs. 0.13 (IQR 0.13) p = 0.003] was significantly higher in females. Our data suggest that SARS-CoV-2 could determine, in a significant proportion of children, kidney damage characterized by hyperfiltration, proteinuria, and hematuria, warranting strict follow-up in these patients. Full article
(This article belongs to the Special Issue Focus on Pediatric Infectious Diseases)
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