Infectious Eye Diseases and Prevention Control

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3455

Special Issue Editor


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Guest Editor
Departments of Ophthalmology and Visual Sciences and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
Interests: retinal diseases

Special Issue Information

Dear Colleagues,

Eye infections from are common and can be severe, potentially leading to vision loss, and in extreme cases, loss of the eye altogether. Depending on the specific site of involvement, ocular microbial infections may cause fungal keratitis, scleritis, or endophthalmitis among others. Various organisms and sites of involvement may cause different ocular complications. Geographic distribution of certain microorganisms and strains such as toxoplasmosis is well known, but the invasiveness or virulence may vary even within species. Therefore, efficient laboratory identification and antimicrobial treatment are undoubtedly critical to prevent vision loss from an eye infections. Unfortunately, substantial gaps exist, such as suboptimal diagnostics and limited antimicrobial choices, and new threats such as antimicrobial resistance are emerging. Considering the vision-threatening nature of eye infections, we hope to invite researchers to contribute to this Special Issue, focused on reducing the medical burden of eye infections. This will require updated knowledge from multifaceted approaches, including epidemiology, novel diagnostics, disease pathogenesis, and prognostic evaluation. Moreover, studies are welcome that adopt in vitro analysis and animal models to elucidate the mechanism of a specific eye infection, a novel diagnostic modality, or a new treatment for these infections.

Dr. Christopher D. Conrady
Guest Editor

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Keywords

  • eye infections
  • ocular microbial infections
  • antimicrobial treatment

Published Papers (3 papers)

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Editorial

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2 pages, 151 KiB  
Editorial
Infectious Eye Diseases and Prevention Control
by Christopher D. Conrady
Microorganisms 2023, 11(5), 1286; https://doi.org/10.3390/microorganisms11051286 - 15 May 2023
Viewed by 722
Abstract
Ocular infections are rare but can be unfortunate, vision-threatening conditions that can affect any part of the eye, from the outer tissues including the episcleral, sclera, and cornea to inside the eye such as the anterior chamber, vitreous, optic nerve, and retina [...] [...] Read more.
Ocular infections are rare but can be unfortunate, vision-threatening conditions that can affect any part of the eye, from the outer tissues including the episcleral, sclera, and cornea to inside the eye such as the anterior chamber, vitreous, optic nerve, and retina [...] Full article
(This article belongs to the Special Issue Infectious Eye Diseases and Prevention Control)

Review

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17 pages, 306 KiB  
Review
Recent Advances in Diagnosis and Treatment Approaches in Fungal Keratitis: A Narrative Review
by Laura Andreea Ghenciu, Alexandra Corina Faur, Sorin Lucian Bolintineanu, Madalina Casiana Salavat and Anca Laura Maghiari
Microorganisms 2024, 12(1), 161; https://doi.org/10.3390/microorganisms12010161 - 13 Jan 2024
Cited by 3 | Viewed by 1417
Abstract
Fungal keratitis represents a potentially sight-threatening infection associated with poor prognosis, as well as financial burden. Novel diagnostic methods include polymerase-chain-reaction (PCR)-based approaches, metagenomic deep sequences, in vivo confocal microscopy, and antifungal susceptibility testing. The ideal therapeutic approaches and outcomes have been widely [...] Read more.
Fungal keratitis represents a potentially sight-threatening infection associated with poor prognosis, as well as financial burden. Novel diagnostic methods include polymerase-chain-reaction (PCR)-based approaches, metagenomic deep sequences, in vivo confocal microscopy, and antifungal susceptibility testing. The ideal therapeutic approaches and outcomes have been widely discussed in recent times, with early therapy being of the utmost importance for the preservation of visual acuity, minimizing corneal damage and reducing the scar size. However, combination therapy can be more efficacious compared to monotherapy. Understanding the pathogenesis, early diagnosis, and prevention strategies can be of great importance. In this narrative, we discuss the recent progress that may aid our understanding of the diagnosis, treatment, and prevention of mycotic keratitis. Full article
(This article belongs to the Special Issue Infectious Eye Diseases and Prevention Control)
17 pages, 922 KiB  
Review
The Host–Pathogen Interplay: A Tale of Two Stories within the Cornea and Posterior Segment
by Michael P. Dempsey and Christopher D. Conrady
Microorganisms 2023, 11(8), 2074; https://doi.org/10.3390/microorganisms11082074 - 12 Aug 2023
Cited by 1 | Viewed by 1028
Abstract
Ocular infectious diseases are an important cause of potentially preventable vision loss and blindness. In the following manuscript, we will review ocular immunology and the pathogenesis of herpesviruses and Pseudomonas aeruginosa infections of the cornea and posterior segment. We will highlight areas of [...] Read more.
Ocular infectious diseases are an important cause of potentially preventable vision loss and blindness. In the following manuscript, we will review ocular immunology and the pathogenesis of herpesviruses and Pseudomonas aeruginosa infections of the cornea and posterior segment. We will highlight areas of future research and what is currently known to promote bench-to-bedside discoveries to improve clinical outcomes of these debilitating ocular diseases. Full article
(This article belongs to the Special Issue Infectious Eye Diseases and Prevention Control)
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