Emerging and Re-emerging Infectious Diseases: Recent Developments on Therapeutics, Clinical Epidemiology and Transmission

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 1762

Special Issue Editors


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Guest Editor
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA 30322, USA
Interests: virology; molecular biology; virus–host interactions; antivirals; antibodies; vector competence
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA 30322, USA
Interests: virology; biochemistry; enzymology; molecular biology; pharmacology

Special Issue Information

Dear Colleagues,

In the modern age, ease of cross-border travelling has become a potent driving force in the emergence and global spread of infectious diseases. In addition to constant viral evolution and adaptation, human and ecological factors, such as the breakdown of public health measures and climate change, have contributed to the emergence and re-emergence of infectious diseases. Hence, the sustained flow of new information is necessary in order to complement and cope with the perpetual challenges caused by these infections. This Special Issue aims to highlight recent scientific and technical developments in novel and improved therapeutic agents and inhibitors, as well as the latest epidemiological data on different emerging and re-emerging infectious diseases. Moreover, we are interested in research outputs on underlying epigenetics and immunologic pathways that may regulate or enhance the transmission and pathogenesis of the involved agents. We welcome original research articles, reviews and case reports based on authors’ research findings and expertise. Our goal is to provide extensive coverage of high-quality research and comprehensive reviews, which we hope will contribute considerably to existing research and benefit the medical community.

Dr. Yee Tsuey Ong
Dr. Adrian Oo
Guest Editors

Manuscript Submission Information

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Keywords

  • infectious disease
  • antiviral
  • antimicrobial
  • therapeutic delivery system
  • epidemiology
  • transmission
  • host factors
  • epigenetics
  • immunology
  • risk factors

Published Papers (1 paper)

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Research

10 pages, 2709 KiB  
Article
Genome Analysis of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus ST398 Strains Isolated from Patients with Invasive Infection
by Abdeljallil Zeggay, Alban Atchon, Benoit Valot, Didier Hocquet, Xavier Bertrand and Kevin Bouiller
Microorganisms 2023, 11(6), 1446; https://doi.org/10.3390/microorganisms11061446 - 30 May 2023
Cited by 1 | Viewed by 1085
Abstract
Background: Using genomic data, we determined the origin of MRSA ST398 isolates responsible for invasive infection in patients with no known livestock contact. Methods: We sequenced the genome of seven MSSA and four MRSA ST398 isolates from patients with invasive infections between 2013 [...] Read more.
Background: Using genomic data, we determined the origin of MRSA ST398 isolates responsible for invasive infection in patients with no known livestock contact. Methods: We sequenced the genome of seven MSSA and four MRSA ST398 isolates from patients with invasive infections between 2013 and 2017, using the Illumina technique. Prophage-associated virulence genes and resistance genes were identified. To determine the origin of the isolates, their genome sequences were included in phylogenetic analysis also encompassing the ST398 genomes available on NCBI. Results: All isolates carried the φSa3 prophage, but with variations in the immune evasion cluster: type C in MRSA isolates, and type B in MSSA isolates. All MSSA belonged to the spa type t1451. MRSA strains had the same SCCmec type IVa (2B) cassette and belonged to spa types t899, t4132, t1939 and t2922. All MRSA harbored the tetracycline resistance gene, tet(M). Phylogenetic analysis revealed that MSSA isolates belonged to a cluster of human-associated isolates, while MRSA isolates belonged to a cluster containing livestock-associated MRSA. Conclusion: We showed that the clinical isolates MRSA and MSSA ST398 have different origins. An acquisition of virulence genes by livestock-associated MRSA isolates allows them to induce an invasive infection in human. Full article
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