Parasitic Infection and Host Immunity, 3rd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 428

Special Issue Editors


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Guest Editor

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Guest Editor
Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica 23890-000, Brazil
Interests: immunology; infection; cellular immunology; chagas disease; leishmaniasis; cryptococcus neoformans; cryptococcus gattii; polyssacharides; macrophages; immunomodulation
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Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue entitled “Parasitic Infection and Host Immunity, 3rd Edition”. Infectious diseases are diseases caused by microorganisms such as viruses, bacteria, protozoa, or fungi, which can be present in the body without causing any damage to the body. However, when there is some change in the host immune system and other clinical conditions, these microorganisms can proliferate, causing disease and facilitating the entry of other microorganisms.

Infectious and contagious diseases can be caused by viruses, fungi, bacteria, or parasites and, depending on the infectious agent, can cause diseases with specific symptoms. Among the main infectious diseases, the following can be mentioned:

(1) Infectious diseases caused by viruses; (2) Infectious diseases caused by bacteria; (3) Infectious diseases caused by fungi; (4) Infectious diseases caused by protozoa; (5) Infectious diseases caused by helminths.

Depending on the microorganism causing the disease, characteristic signs and symptoms of the disease may appear, the most common being headache, fever, nausea, weakness, and feeling unwell and tired, especially in the initial phase of the infectious process. However, depending on the disease, more serious symptoms may appear, such as an enlarged liver, stiff neck, convulsions, and coma, for example. Infectious diseases can be acquired through direct contact with the infectious agent or through exposure of the person to contaminated water or food as well as through respiratory, sexual, or animal injuries. These diseases can also often be transmitted from person to person, and are termed infectious diseases in these cases.

This Special Issue aims to review or describe the latest findings regarding the immunopathology, epidemiology, and diagnostic tools in parasitic infection of microorganisms and host immunity. The ultimate goal is to provide readers with new insights into the current and future state of the diagnosis and treatment procedures and pathologies for these diseases.

For this Special Issue, original research articles and reviews are welcome. Research areas of interest may include (but are not limited to) the following: epidemiology of human and animal infectious diseases, immunopathology of human and animal infectious diseases, and clinical treatment and diagnosis of humans. We look forward to receiving your contributions.

Dr. Célio Geraldo Freire-de-Lima
Dr. Debora Decote-Ricardo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infectious diseases
  • parasite infection
  • host-parasite interaction
  • immunomodulation
  • immunopathology
  • epidemiology

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Published Papers (1 paper)

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Research

18 pages, 1143 KB  
Article
The Capsular Polysaccharides GXM and GXMGal from Cryptococcus neoformans Modulate Macrophages Infected with Leishmania major
by Idália Maria Ferreira-dos-Santos, Elias Barbosa da Silva-Junior, Afonso Santine M. M. Velez, Leonardo Freire-de-Lima, Alexandre Morrot, Marco Edilson Freire de Lima, Gustavo José Makhoul, Joyce Cristina Guimarães-de-Oliveira, Israel Diniz-Lima, Luciana Polaco Covre, Renata Quintanilha dos Santos, Fernanda de Paula Pepino, Letícia Seabra Abrantes, Lucia Helena Pinto-da-Silva, José Osvaldo Previato, Lucia Mendonça-Previato, Celio Geraldo Freire-de-Lima and Debora Decote-Ricardo
Microorganisms 2025, 13(10), 2272; https://doi.org/10.3390/microorganisms13102272 - 28 Sep 2025
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Abstract
Leishmania spp. are obligatory intracellular parasites that primarily infect macrophages. The macrophage immune response plays a pivotal role in determining the control or progression of infection. “M1-like” macrophages mediate parasite clearance through the production of nitric oxide, pro-inflammatory cytokines, and reactive oxygen species, [...] Read more.
Leishmania spp. are obligatory intracellular parasites that primarily infect macrophages. The macrophage immune response plays a pivotal role in determining the control or progression of infection. “M1-like” macrophages mediate parasite clearance through the production of nitric oxide, pro-inflammatory cytokines, and reactive oxygen species, whereas “M2-like” macrophages contribute to infection progression by exerting anti-inflammatory effects. The capsular polysaccharides Glucuronoxylomannan (GXM) and glucuronoxylomannogalactan (GXMGal) from Cryptococcus neoformans are capable of immunomodulating the macrophage response. GXM exhibits immunoregulatory activity, whereas GXMGal induces a pro-inflammatory response. Although the activity of these polysaccharides has been studied in cryptococcosis, their immunomodulatory potential in other infectious models remains largely unexplored. Here, we investigated the effects of GXM and GXMGal on Leishmania major infection in murine peritoneal macrophages. Murine peritoneal macrophages were infected with L. major and, 24 h post-infection, treated with 50 μg of either GXM or GXMGal. Our data revealed that GXM treatment enhanced L. major infection, while GXMGal treatment had no significant effect on the parasitic load in infected macrophages. Full article
(This article belongs to the Special Issue Parasitic Infection and Host Immunity, 3rd Edition)
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