Candida albicans Virulence Factors and Its Pathogenecity

Dear Colleagues,

Candida albicans lives commensally on the skin and mucosal surfaces of genital, intestinal, vaginal, urinary and oral tracts of 80% of healthy individuals. An imbalance between the host immunity and this opportunistic fungus may trigger mucosal infections followed by dissemination via bloodstream and infection of internal organs. Candida albicans is considered the most common opportunistic pathogenic fungus in humans and a causative agent of 60% of mucosal infections and 40% of candidemia cases. Several virulence factors are known to be responsible for Candida infections, such as adherence to host surfaces, biofilm formation and secretion of hydrolytic enzymes. Moreover, Candida resistance to traditional antimicrobial agents, especially the ones from azole group, is well known, especially when Candida cells are in biofilm form.

The aim of this Special Issue is to gather more information on the important human pathogen, Candida albicans. We would like to invite researchers to submit their research or review articles on Candida albicans concerning different aspects, such as virulent factors, resistance to antimicrobial agents, new therapies, molecular pathways and host interactions.

Prof. Dr. Mariana Henriques
Dr. Sónia Carina Silva
Guest Editors

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