Research on Fungal Pathogen Candida spp. and Alternative Therapy
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 3717
Special Issue Editor
Interests: drug resistance; biofilm; cell wall proteins; Candida spp.; Malassezia spp.
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Candida is the most common fungal pathogen associated with nosocomial infections. Invasive candidiasis is a serious infection that primarily affects immunocompromised patients. Candida albicans, usually susceptible to fluconazole, has long been the most common species involved in both invasive and mucocutaneous infections. However, with the increasing use of antifungal agents and new diagnostic techniques, the epidemiology of Candida infections is changing, with an increased incidence of infections caused by other Candida species.
Several factors play an important role in the pathogenesis of Candida spp.: morphological and phenotypic variation, biofilm formation, production of extracellular enzymes toxic to tissues, adaptation to different environments, adhesion and invasion, production of heat shock proteins (HSPs), evasion of the host immune system, synergistic coaggregation with the resident microbiota, resistance to antifungal agents and the ability to respond effectively to multiple stresses. In the establishment of Candida infections, all these factors play an important role.
In this Special Issue of Microorganisms, we invite you to send contributions, in the form of original research or review papers, that report on the most advanced methods to study any aspects of the expression of virulence factors in Candida spp. Such topics might include studies on the production of extracellular enzymes, biofilm formation, and the production of heat shock proteins. Other topics might include the description of the evasion of the host immune system, or the study of alternative compounds as antifungal and anti-virulence factors.
Dr. Letizia Angiolella
Guest Editor
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Keywords
- Candida spp.
- yeast
- heat shock proteins
- biofilm
- evasion of host immunity
- hydrolytic enzyme
- adhesion
- alternative compounds
- synergistic activity with microbiota
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