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Microorganisms
Special Issues
Virus-Driven Skin Diseases
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Virus-Driven Skin Diseases

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 2028

Special Issue Editors

Dr. Luisa Zupin

E-Mail Website
Guest Editor
Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
Interests: genetics; photobiomodulation therapy
Dr. Chiara Moltrasio

E-Mail Website
Guest Editor
Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Interests: clinical or molecular genetics and immunobiology of autoimmune and autoinflammatory skin disorders including, among others, hidradenitis suppurativa and pyoderma gangrenosum; genetics of infectious diseases; genodermatoses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the vast world of dermatology and infectious diseases, virus driven skin infections account for a significant percentage. In the recent years, various skin diseases driven by different viruses, including zoonotic viruses infection (e.g., caused by monkeypox and ebola viruses), herpes viruses infection (e.g., produced by herpes simplex 1/2 and varicella zoster viruses), viral childhood exanthems (e.g., induced by measles, rubella and chickenpox viruses) or disorders caused by other viral agents, such as molluscum contagiosum and human papilloma virus, have been increasingly explored from both clinical and pathophysiological perspectives.

The clinical variability of these entities may rely on the combination of viral genome diversity, viral proteins, and their interaction with the host antiviral immune response.

The aim of this special issue is to inspire the community by exploring new approaches and perspectives on the mechanisms underlying virus driven skin diseases, connecting basic virology and immunology research to clinical observations to support a better comprehension of the infections and an ameliorated management of the patients infected with these viruses.

We encourage researchers in these fields to contribute with original articles, reviews, communications on the clinics and pathophysiology of virus driven skin diseases, improving the knowledge of the virus driven skin diseases in favor of patients’ management.

Dr. Luisa Zupin
Dr. Chiara Moltrasio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

18 pages, 6717 KiB  
Article
Dermatologic Changes in Experimental Model of Long COVID
by Hussain Hussain, Michael J. Paidas, Ramamoorthy Rajalakshmi, Aya Fadel, Misha Ali, Pingping Chen and Arumugam R. Jayakumar
Microorganisms 2024, 12(2), 272; https://doi.org/10.3390/microorganisms12020272 - 27 Jan 2024
Cited by 2 | Viewed by 1783
Abstract
The coronavirus disease-19 (COVID-19) pandemic, declared in early 2020, has left an indelible mark on global health, with over 7.0 million deaths and persistent challenges. While the pharmaceutical industry raced to develop vaccines, the emergence of mutant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [...] Read more.
The coronavirus disease-19 (COVID-19) pandemic, declared in early 2020, has left an indelible mark on global health, with over 7.0 million deaths and persistent challenges. While the pharmaceutical industry raced to develop vaccines, the emergence of mutant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) strains continues to pose a significant threat. Beyond the immediate concerns, the long-term health repercussions of COVID-19 survivors are garnering attention, particularly due to documented cases of cardiovascular issues, liver dysfunction, pulmonary complications, kidney impairments, and notable neurocognitive deficits. Recent studies have delved into the pathophysiological changes in various organs following post-acute infection with murine hepatitis virus-1 (MHV-1), a coronavirus, in mice. One aspect that stands out is the impact on the skin, a previously underexplored facet of long-term COVID-19 effects. The research reveals significant cutaneous findings during both the acute and long-term phases post-MHV-1 infection, mirroring certain alterations observed in humans post-SARS-CoV-2 infection. In the acute stages, mice exhibited destruction of the epidermal layer, increased hair follicles, extensive collagen deposition in the dermal layer, and hyperplasticity of sebaceous glands. Moreover, the thinning of the panniculus carnosus and adventitial layer was noted, consistent with human studies. A long-term investigation revealed the absence of hair follicles, destruction of adipose tissues, and further damage to the epidermal layer. Remarkably, treatment with a synthetic peptide, SPIKENET (SPK), designed to prevent Spike glycoprotein-1 binding with host receptors and elicit a potent anti-inflammatory response, showed protection against MHV-1 infection. Precisely, SPK treatment restored hair follicle loss in MHV-1 infection, re-architected the epidermal and dermal layers, and successfully overhauled fatty tissue destruction. These promising findings underscore the potential of SPK as a therapeutic intervention to prevent long-term skin alterations initiated by SARS-CoV-2, providing a glimmer of hope in the battle against the lingering effects of the pandemic. Full article
(This article belongs to the Special Issue Virus-Driven Skin Diseases)
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