Mathematical Modeling in Computational Biology and Bioinformatics

Dear Colleagues,

In every domain of biology, from molecular structures to ecosystem dynamics, mathematics has played a vital role. The interplay between biological theories and mathematical models has facilitated profound insights, guided experimental methods, and elucidated complex biological processes. Mathematical modeling, integral to the scientific methodology in biology, starts from foundational assumptions, extending to logical conclusions that must be critically evaluated against empirical data. In recent times, the capability to validate or challenge these conclusions has dramatically increased with the influx of extensive databases such as genomic sequences and protein structures, allied with advancements in mathematical fields such as network theory, complex systems, and the development of bioinformatics accompanied with computer programming advances and web platforms. This Special Issue aims to illustrate the pivotal role of mathematical models in advancing biological knowledge and enhancing the interpretation of experimental results. It will highlight how integrating mathematical models with experimental biology can address both longstanding and contemporary challenges while also pushing forward the boundaries of what we understand about life's complexity.

With a focus on the intersection of mathematics and various biological disciplines, for this Special Issue, we are seeking contributions that utilize innovative mathematical methods and novel data analysis techniques. We welcome articles including, but not limited to, the following themes:

• Fractal physiology
• Mathematical epidemiology
• Signaling networks and circuits
• Evolutionary dynamics at multiple scales
• Dynamics of the microbiome

By showcasing original research and comprehensive reviews, this Special Issue aims to encompass both fundamental and applied aspects of biology, offering new perspectives and tools to the biological sciences community.

Prof. Dr. Marco V. José
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Mathematics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.