Glycolipids from Marine Bacteria

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3593

Special Issue Editor


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Guest Editor
Department of Chemical Sciences, University of Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, I-80126 Napoli, Italy
Interests: lipopolysaccharides; glycoconjugates; extracellular polysaccharide; capsular polysaccharide; NMR spectroscopy; anti-biofilm molecules; mass spectrometry; cold-adapted bacteria
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Special Issue Information

Dear Colleagues,

The growing interest in the search of bioactive molecules has led scientists to focus on marine environments. Marine and marine extremophilic habitats represent the reservoir for more than 50% of total biomass of prokaryotes in the world.

Bacterial glycolipids are complex amphipathic molecules containing one or more monosaccharide residues linked to a hydrophobic moiety, such as an acylglycerol, a sphingoid backbone, a ceramide or a prenyl phosphate. They are collectively included in a larger family of substances known as glycoconjugates, together with the lipopolysaccharides (LPSs) and the capsular polysaccharides, anchored to the cell membrane through a lipid moiety.

Bacterial glycolipids are involved in the organization and function of bacterial membranes and play a role in the activation of the immune system of the host. Furthermore, glycolipids extracted from marine bacteria have been shown to possess several relevant biological properties including antiviral, anti-tumor, anti-inflammatory, and immunomodulant activities.

This Special Issue aims to collect as many papers as possible to summarize the state-of-the-art concerning the isolation, structural characterization, and biological activity of the glycolipids produced by marine bacteria.

Dr. Angela Casillo
Guest Editor

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Keywords

  • marine bacteria
  • marine extremophiles
  • glycolipids
  • glycosphingolipids
  • glycoglycerolipids
  • lipopolysaccharide
  • structural characterization, natural products

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Published Papers (1 paper)

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Research

11 pages, 3258 KiB  
Article
Detailed Structural Characterization of the Lipooligosaccharide from the Extracellular Membrane Vesicles of Shewanella vesiculosa HM13
by Rossella Di Guida, Angela Casillo, Fumiaki Yokoyama, Jun Kawamoto, Tatsuo Kurihara and Maria Michela Corsaro
Mar. Drugs 2020, 18(5), 231; https://doi.org/10.3390/md18050231 - 27 Apr 2020
Cited by 11 | Viewed by 2909
Abstract
Bacterial extracellular membrane vesicles (EMVs) are membrane-bound particles released during cell growth by a variety of microorganisms, among which are cold-adapted bacteria. Shewanella vesiculosa HM13, a cold-adapted Gram-negative bacterium isolated from the intestine of a horse mackerel, is able to produce a large [...] Read more.
Bacterial extracellular membrane vesicles (EMVs) are membrane-bound particles released during cell growth by a variety of microorganisms, among which are cold-adapted bacteria. Shewanella vesiculosa HM13, a cold-adapted Gram-negative bacterium isolated from the intestine of a horse mackerel, is able to produce a large amount of EMVs. S. vesiculosa HM13 has been found to include a cargo protein, P49, in the EMVs, but the entire mechanism in which P49 is preferentially included in the vesicles has still not been completely deciphered. Given these premises, and since the structural study of the components of the EMVs is crucial for deciphering the P49 transport mechanism, in this study the complete characterization of the lipooligosaccharide (LOS) isolated from the cells and from the EMVs of S. vesiculosa HM13 grown at 18 °C is reported. Both lipid A and core oligosaccharide have been characterized by chemical and spectroscopic methods. Full article
(This article belongs to the Special Issue Glycolipids from Marine Bacteria)
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