Application of Chitosan and/or Chitin Nanofibrils in Medical Treatment
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 10563
Special Issue Editor
Interests: chitosan; chitin; bone grafting; hemostatic; wound dressing; tissue engineering; 3D bioprinting
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Due to recent advances in biology and medicine, the problems of creating materials that can (partially or completely) replace human or animal organs were brought to the fore. A matrix for tissue engineering constructions should provide adhesion, proliferation, and differentiation of cells, be biocompatible and non-toxic, and possess a certain mechanical strength and elasticity parameters that are necessary for manipulations with these materials in liquid media. Chitosan is the most promising polymer for tissue engineering applications since it possesses the above properties. However, this polymer is highly hydrophilic; therefore, chitosan-based materials are unstable in the wet state, and their strength decreases in aqueous media. In this connection, the use of biocompatible organic nanoparticles as chitin nanofibrils is particularly important for regulating properties of chitosan matrices. Different methods are used to process one-, two-, and three-dimensional matrices based on chitosan and chitin nanofibrils. They are the wet spinning method for producing composite fibers; electrospinning for producing nanofibers cloth; lyophilization of chitosan solutions and their mixtures with nanoparticles to form porous three-dimensional matrices; and, finally, 3D bioprinting. The materials thus developed to form fibers, films, tubular samples, and sponges can be used as surgical suture threads, effective wound dressing, blood vessels, hemostatic materials, and others. However, despite considerable success reached in chitosan and/or chitin nanofibril-based biomaterials, materials that fully comply with the requirements of tissue engineering and medicine are still not developed.
This Special Issue on “Application of Chitosan and/or Chitin Nanofibrils in Medical Treatment” will provide a platform for researchers to publish studies using these biopolymers in tissue engineering contexts. We welcome innovative research on biomedical and therapeutic applications of chitosan and chitin nanofibrils.
Dr. Vladimir Eugenievich Yudin
Guest Editor
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Keywords
- chitosan
- chitin nanofibrils
- tissue engineering
- regenerative medicine
- pharmaceutical
- biotechnology
- chemical modification
- physical modification
- 3D bioprinting
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