Marine-Derived Compounds Applied in Skin Disease

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 4500

Special Issue Editor


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Guest Editor
Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL, USA
Interests: organic/medicinal chemistry; drug discovery and development; anti-cancer and anti-infective agents; synthesis of marine natural products and their analogs; structure based drug design; SAR studies and lead optimization
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Special Issue Information

Dear Colleagues,

Marine natural products continue to be a valuable source of drug leads. Many of these compounds are anticancer agents that have a potential therapeutic value. These compounds are generally identified based on bioactivity screens and their mode of action is largely unknown at the time of their discovery. Discerning their mode of action is a critical step in their further development as potential drugs. This Special Issue focuses on such marine derived natural products and their analogs that have shown activity against skin cancer or in general skin diseases. The main focus of this Special Issue is on the bioactivities of the lead compounds, their mode of action and their potential use in drug discovery. We aim to publish original research articles and review articles in this Special Issue.

Prof. Dr. Sadanandan E. Velu
Guest Editor

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Keywords

  • marine natural product
  • alkaloid analogs
  • skin disease
  • skin cancer
  • melanoma
  • anticancer
  • drug discovery
  • inhibitors

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Published Papers (1 paper)

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Research

12 pages, 3045 KiB  
Article
Anti-Acne Effects of Cembrene Diterpenoids from the Cultured Soft Coral Sinularia flexibilis
by Li-Wei Chen, Hsuan-Lien Chung, Ching-Chiung Wang, Jui-Hsin Su, Yu-Ju Chen and Chia-Jung Lee
Mar. Drugs 2020, 18(10), 487; https://doi.org/10.3390/md18100487 - 25 Sep 2020
Cited by 17 | Viewed by 3946
Abstract
Acne is a skin disease common in adolescents and increasingly common in the adult population. The major pathologic events of acne vulgaris include increased sebum production, retention hyperkeratosis, carrying commensal skin microbiota, and inflammation. In recent years, more than 10,000 compounds have been [...] Read more.
Acne is a skin disease common in adolescents and increasingly common in the adult population. The major pathologic events of acne vulgaris include increased sebum production, retention hyperkeratosis, carrying commensal skin microbiota, and inflammation. In recent years, more than 10,000 compounds have been isolated and identified from marine organisms. The aim of this study was to discover the potential anti-acne activity of fraction 9 + 10 (SF-E) of Sinularia flexibilis extract and six cembrene diterpenoids. We found that the SF-E significantly reduced Cutibacterium acnes-induced edema in Wistar rat ears. The cembrene diterpenoids including 11-dehydrosinulariolide (SC-2), 3,4:8,11-bisepoxy-7-acetoxycembra-15(17)-en-1,12-olide (SC-7), and sinularin (SC-9) reduced nitric oxide (NO) production with 50% inhibitory concentration of 5.66 ± 0.19, 15.25 ± 0.25, and 3.85 ± 0.25 μM, respectively, and inducible NO synthase expression in RAW 264.7 cells. Moreover, treatment with SC-2, SC-7, and SC-9 significantly suppressed lipopolysaccharide- and heat-killed C. acnes-induced expression of proteins involved in mitogen-activated protein kinase pathway in both RAW 264.7 and HaCaT cells. After treatment with SC-2, SC-7, and SC-9, over-proliferation of HaCaT cells was significantly terminated. In summary, SC-2, SC-7, and SC-9 showed anti-inflammatory effects in RAW 264.7 cells, suggesting that these cembrene diterpenoids obtained from S. flexibilis are natural marine products with potential anti-acne activities. Full article
(This article belongs to the Special Issue Marine-Derived Compounds Applied in Skin Disease)
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