Special Issue "Marine-Derived Compounds Applied in Skin Disease"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 2513

Special Issue Editor

Prof. Dr. Sadanandan E. E. Velu
E-Mail Website
Guest Editor
Department of Chemistry, University of Alabama at Birmingham, Alabama, USA
Interests: organic/medicinal chemistry; drug discovery and development; anti-cancer and anti-infective agents; synthesis of marine natural products and their analogs; structure based drug design; SAR studies and lead optimization
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Special Issue Information

Dear Colleagues,

Marine natural products continue to be a valuable source of drug leads. Many of these compounds are anticancer agents that have a potential therapeutic value. These compounds are generally identified based on bioactivity screens and their mode of action is largely unknown at the time of their discovery. Discerning their mode of action is a critical step in their further development as potential drugs. This Special Issue focuses on such marine derived natural products and their analogs that have shown activity against skin cancer or in general skin diseases. The main focus of this Special Issue is on the bioactivities of the lead compounds, their mode of action and their potential use in drug discovery. We aim to publish original research articles and review articles in this Special Issue.

Prof. Dr. Sadanandan E. Velu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural product
  • alkaloid analogs
  • skin disease
  • skin cancer
  • melanoma
  • anticancer
  • drug discovery
  • inhibitors

Published Papers (1 paper)

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Research

Article
Anti-Acne Effects of Cembrene Diterpenoids from the Cultured Soft Coral Sinularia flexibilis
Mar. Drugs 2020, 18(10), 487; https://doi.org/10.3390/md18100487 - 25 Sep 2020
Cited by 5 | Viewed by 2259
Abstract
Acne is a skin disease common in adolescents and increasingly common in the adult population. The major pathologic events of acne vulgaris include increased sebum production, retention hyperkeratosis, carrying commensal skin microbiota, and inflammation. In recent years, more than 10,000 compounds have been [...] Read more.
Acne is a skin disease common in adolescents and increasingly common in the adult population. The major pathologic events of acne vulgaris include increased sebum production, retention hyperkeratosis, carrying commensal skin microbiota, and inflammation. In recent years, more than 10,000 compounds have been isolated and identified from marine organisms. The aim of this study was to discover the potential anti-acne activity of fraction 9 + 10 (SF-E) of Sinularia flexibilis extract and six cembrene diterpenoids. We found that the SF-E significantly reduced Cutibacterium acnes-induced edema in Wistar rat ears. The cembrene diterpenoids including 11-dehydrosinulariolide (SC-2), 3,4:8,11-bisepoxy-7-acetoxycembra-15(17)-en-1,12-olide (SC-7), and sinularin (SC-9) reduced nitric oxide (NO) production with 50% inhibitory concentration of 5.66 ± 0.19, 15.25 ± 0.25, and 3.85 ± 0.25 μM, respectively, and inducible NO synthase expression in RAW 264.7 cells. Moreover, treatment with SC-2, SC-7, and SC-9 significantly suppressed lipopolysaccharide- and heat-killed C. acnes-induced expression of proteins involved in mitogen-activated protein kinase pathway in both RAW 264.7 and HaCaT cells. After treatment with SC-2, SC-7, and SC-9, over-proliferation of HaCaT cells was significantly terminated. In summary, SC-2, SC-7, and SC-9 showed anti-inflammatory effects in RAW 264.7 cells, suggesting that these cembrene diterpenoids obtained from S. flexibilis are natural marine products with potential anti-acne activities. Full article
(This article belongs to the Special Issue Marine-Derived Compounds Applied in Skin Disease)
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