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Research on Marine Antimicrobial Peptides

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Chemoecology for Drug Discovery".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 8185

Special Issue Editors

Ministry of Agriculture of the People's Republic of China, Beijing, China
Interests: design and modification of marine antimicrobial peptide; mechanism of action; antibiofilm
Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China
Interests: antimicrobial peptides; antibacterial compounds; bacteria; biofilms; intracellular bacteria

Special Issue Information

Dear Colleagues,

The marine ecosystem, harboring Earth’s richest biodiversity, has evolved unique bioactive molecules—marine antimicrobial peptides (AMPs)—under extreme environmental pressures. Compared to terrestrial counterparts, marine AMPs exhibit distinct advantages: their structural diversity, derived from the evolutionary adaptations of marine organisms (e.g., sponges, mollusks, and deep-sea microbes), enables broad-spectrum antimicrobial activity, low host toxicity, and reduced propensity to induce drug resistance, offering novel solutions to combat multidrug-resistant pathogens. Recent advances in high-throughput sequencing, metagenomic mining, and AI-based prediction technologies have significantly accelerated the discovery and functional characterization of novel marine AMPs. Innovations in synthetic biology and nanoparticle-based delivery systems further enhance their potential in anti-infective therapies, biocontrol, and tissue engineering applications. This Special Issue highlights cutting-edge research on marine AMP resource exploration, mechanistic studies, and translational developments, aiming to foster interdisciplinary collaborations for next-generation antimicrobial strategies.

We cordially invite researchers worldwide to contribute original research and reviews to advance the sustainable exploitation of marine-derived therapeutics and build innovative frameworks for drug discovery.

Dr. Na Yang
Dr. Xiao Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine antimicrobial peptides
  • structural diversity
  • host defense mechanisms
  • multidrug-resistant pathogens
  • mining and exploration
  • biosynthesis
  • anti-infective mechanism
  • immunoregulation
  • nanoparticle-based delivery systems
  • AI-based prediction technologies

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Published Papers (3 papers)

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Research

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17 pages, 1983 KB  
Article
Isolation and Characterization of St-CRPs: Cysteine-Rich Peptides from the Arctic Marine Ascidian Synoicum turgens
by Ida K. Ø. Hansen, Philip B. Rainsford, Johan Isaksson, Kine Ø. Hansen, Klara Stensvåg, Anastasia Albert, Terje Vasskog and Tor Haug
Mar. Drugs 2026, 24(5), 168; https://doi.org/10.3390/md24050168 - 8 May 2026
Viewed by 1760
Abstract
Ascidians are a group of marine invertebrates, most of which are sessile and soft-bodied. Their lack of an adaptive immune system makes them rely on innate immune responses to detect and eliminate invading microbes. Antimicrobial peptides (AMPs) play an essential part in this [...] Read more.
Ascidians are a group of marine invertebrates, most of which are sessile and soft-bodied. Their lack of an adaptive immune system makes them rely on innate immune responses to detect and eliminate invading microbes. Antimicrobial peptides (AMPs) play an essential part in this process. In this paper, we present the isolation, structure elucidation, and bioactivities of two new cysteine-rich peptides (CRPs) from the Arctic marine ascidian Synoicum turgens. The sequences and structures of the peptides were determined by Edman degradation sequencing, mass spectrometry, and NMR analysis. This revealed two novel 2 kDa peptides, St-CRP-1 and St-CRP-2, with neutral net charge and C-terminal amidation. St-CRP-1 consisted of 18 amino acids and displayed selective and moderate growth inhibition of two Gram-positive bacterial strains (Bacillus subtilis and Corynebacterium glutamicum) at 24.6 µM, whereas St-CRP-2 consisted of 19 amino acids and inhibited the growth of B. subtilis at 49.2 µM. St-CRP-1 had no effect on two mammalian cell lines or the brine shrimp Artemia salina at the highest concentration tested. Structural analysis of the St-CRPs indicated a Cys1–Cys6, Cys2–Cys4, and Cys3–Cys5 disulfide connectivity, which is also found in alpha-defensins. The results from this study show that Arctic marine ascidians are a rich source of novel bioactive peptides. Full article
(This article belongs to the Special Issue Research on Marine Antimicrobial Peptides)
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33 pages, 25820 KB  
Article
Novel Anti-MRSA Peptide from Mangrove-Derived Virgibacillus chiguensis FN33 Supported by Genomics and Molecular Dynamics
by Namfa Sermkaew, Apichart Atipairin, Phetcharat Boonruamkaew, Sucheewin Krobthong, Chanat Aonbangkhen, Jumpei Uchiyama, Yodying Yingchutrakul and Nuttapon Songnaka
Mar. Drugs 2025, 23(5), 209; https://doi.org/10.3390/md23050209 - 14 May 2025
Cited by 2 | Viewed by 2685
Abstract
Antimicrobial resistance (AMR) is a global health threat, with methicillin-resistant Staphylococcus aureus (MRSA) being one of the major resistant pathogens. This study reports the isolation of a novel mangrove-derived bacterium, Virgibacillus chiguensis FN33, as identified through genome analysis and the discovery of a [...] Read more.
Antimicrobial resistance (AMR) is a global health threat, with methicillin-resistant Staphylococcus aureus (MRSA) being one of the major resistant pathogens. This study reports the isolation of a novel mangrove-derived bacterium, Virgibacillus chiguensis FN33, as identified through genome analysis and the discovery of a new anionic antimicrobial peptide (AMP) exhibiting anti-MRSA activity. The AMP was composed of 23 amino acids, which were elucidated as NH3-Glu-Gly-Gly-Cys-Gly-Val-Asp-Thr-Trp-Gly-Cys-Leu-Thr-Pro-Cys-His-Cys-Asp-Leu-Phe-Cys-Thr-Thr-COOH. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for MRSA were 8 µg/mL and 16 µg/mL, respectively. FN33 AMP induced cell membrane permeabilization, suggesting a membrane-disrupting mechanism. The AMP remained stable at 30–40 °C but lost activity at higher temperatures and following exposure to proteases, surfactants, and extreme pH. All-atom molecular dynamics simulations showed that the AMP adopts a β-sheet structure upon membrane interaction. These findings suggest that Virgibacillus chiguensis FN33 is a promising source of novel antibacterial agents against MRSA, supporting alternative strategies for drug-resistant infections. Full article
(This article belongs to the Special Issue Research on Marine Antimicrobial Peptides)
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Review

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36 pages, 1848 KB  
Review
Marine Antimicrobial Peptides: Advances in Discovery, Multifunctional Mechanisms, and Therapeutic Translation Challenges
by Bin Gao, Na Yang, Da Teng, Ya Hao, Jianhua Wang and Ruoyu Mao
Mar. Drugs 2025, 23(12), 463; https://doi.org/10.3390/md23120463 - 1 Dec 2025
Cited by 5 | Viewed by 3161
Abstract
The pervasive misuse of antibiotics has precipitated a global crisis of antimicrobial resistance (AMR), epitomized by the proliferation of methicillin-resistant Staphylococcus aureus (MRSA). Marine-derived antimicrobial peptides (AMPs) have emerged as promising alternatives, exhibiting broad therapeutic potential, including antimicrobial and anticancer activities. This review [...] Read more.
The pervasive misuse of antibiotics has precipitated a global crisis of antimicrobial resistance (AMR), epitomized by the proliferation of methicillin-resistant Staphylococcus aureus (MRSA). Marine-derived antimicrobial peptides (AMPs) have emerged as promising alternatives, exhibiting broad therapeutic potential, including antimicrobial and anticancer activities. This review summarizes recent advances in marine AMPs, encompassing resource exploration, preparation methods, and biomedical applications, while addressing challenges such as instability and limited scalability. Future perspectives emphasize rational AMPs design to enhance efficacy and safety, alongside synergistic combination strategies, underscoring the potential of marine AMPs as viable interventions against drug-resistant pathogens. Full article
(This article belongs to the Special Issue Research on Marine Antimicrobial Peptides)
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