Marine Transcriptomic

Dear Colleagues,

Advances in bioinformatics and the increasing availability of sequenced genomes and transcriptomes provide more opportunities than ever in the discovery of novel bioactive compounds and biocatalysts from marine organisms.

In silico analysis of genomic or transcriptomic data is easier and more efficient today thanks to the development of new bioinformatics tools allowing access to multiple pieces of information and functionalities.

RNA-Sequencing allows detecting both known and novel features, to access differential expressions, gene networks, functions likely to reveal new molecules of interest.

For example, many microorganisms have the potential to produce a far greater number of natural products than have been isolated to date, since most biosynthetic gene clusters are either silent or expressed at very low levels when they are cultured under standard laboratory conditions.

On the other hand, in silico analysis of transcriptomes from other marine organisms such as venomous animals or organisms from extreme environments provides a considerable opportunity to identify new molecules with global health potential.

The identification of biosynthetic gene and gene clusters through a bioinformatics approach and their synthesis by eventual heterologous expression, will give a great impulse for natural products identification and drug discovery from marine organisms.

Dr. Céline Zatylny-Gaudin
Guest Editor

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