Active Compounds from Sea Cucumber

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 7836

Special Issue Editor


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Guest Editor
Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche
Interests: actinobacteria; endophytes; sponge-associated; antibiotics; sea cucumbers; saponins; microalgae; macroalgae

Special Issue Information

Dear Colleagues,

Sea cucumbers are marine animals with an interesting lifestyle and a unique system of defense. They have different pharmacological, nutraceutical and medicinal activities due to the remarkable differences in the type and quantity of compounds they produce. Sea cucumbers are referred to as “marine ginseng” since they have been used either whole or in part in traditional folk medicine in many Asian countries to cure diseases like rheumatoid arthritis, joint pain, tendonitis, osteoarthritis, cardiovascular, ankylosing spondylitis, arthralgia, tumors, fungal infection, gastric, impotence, frequent urination and kidney deficiency, high blood pressure and muscular disorders.

Therefore, it is recognized that these holothurians have the ability to generate a wide range of distinctive biologically and pharmacologically important compounds with diverse chemistries which include saponins (triterpene glycosides), fatty acids, lipids, minerals, carotenoids, sphingosine, bioactive proteins (enzymes, collagen, gelatine, peptides, amino acids), vitamins, carbohydrates, mucopolysaccharides, glycosaminoglycan (GAGS, chondroitin/fucan sulphates), fucoidan, phenolics and flavonoids.

This Special Issue on “Active Compounds from Sea Cucumbers” aims to collate contributions on the latest information on the discovery, characterization, biological, pharmacological and medical evaluation and modes of actions of the many compounds from sea cucumbers. The presence and power of these active ingredients have led to a rapid growth and development in various biomedical and functional food applications which are important to human health.

Prof. Cusimano Maria Grazia
Guest Editor

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Keywords

  • Sea cucumber
  • Saponins
  • Body wall
  • Viscera
  • Cuvierian tubules
  • Fucose; mode of action
  • Carotenoid
  • Peptides
  • GAGS
  • Sphingosine

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Published Papers (2 papers)

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Research

13 pages, 2441 KiB  
Article
Preparation of Antioxidant Peptide by Microwave- Assisted Hydrolysis of Collagen and Its Protective Effect Against H2O2-Induced Damage of RAW264.7 Cells
by Yan Li, Jie Li, Sai-Jun Lin, Zui-Su Yang and Huo-Xi Jin
Mar. Drugs 2019, 17(11), 642; https://doi.org/10.3390/md17110642 - 14 Nov 2019
Cited by 54 | Viewed by 4341
Abstract
Antioxidant peptides have elicited interest for the versatility of their use in the food and pharmaceutical industry. In the current study, antioxidant peptides were prepared by microwave-assisted alkaline protease hydrolysis of collagen from sea cucumber (Acaudina molpadioides). The results showed that [...] Read more.
Antioxidant peptides have elicited interest for the versatility of their use in the food and pharmaceutical industry. In the current study, antioxidant peptides were prepared by microwave-assisted alkaline protease hydrolysis of collagen from sea cucumber (Acaudina molpadioides). The results showed that microwave irradiation significantly improved the degree of hydrolysis of collagen and the hydroxyl radical (OH⋅) scavenging activity of hydrolysate. The content and OH⋅ scavenging activity of collagen peptides with molecular weight ≤ 1 kDa (CPS) in the hydrolysate obtained at 250 W increased significantly compared with the non-microwave-assisted control. CPS could scavenge OH⋅ and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical in a dose-dependent manner. The scavenging activity of OH⋅ and DPPH radical was 93.1% and 41.2%, respectively, at CPS concentration of 1 mg/mL. CPS could significantly promote RAW264.7 cell proliferation and reduce the Reactive Oxygen Species (ROS) level of H2O2-induced damage in RAW264.7 cells in a dose-dependent manner. Furthermore, all CPS-treated groups exhibited an increase in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and a decrease in malondialdehyde (MDA) level compared with the control. These results showed that CPS could effectively protect RAW264.7 cells from H2O2-induced damage, implying the potential utilization of CPS as a natural antioxidant for food and pharmaceutical applications. Full article
(This article belongs to the Special Issue Active Compounds from Sea Cucumber)
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9 pages, 1071 KiB  
Article
Modulation of Doxorubicin Intracellular Accumulation and Anticancer Activity by Triterpene Glycoside Cucumarioside A2-2
by Ekaterina Menchinskaya, Tatiana Gorpenchenko, Alexandra Silchenko, Sergey Avilov and Dmitry Aminin
Mar. Drugs 2019, 17(11), 597; https://doi.org/10.3390/md17110597 - 23 Oct 2019
Cited by 10 | Viewed by 3122
Abstract
The effect of treatment of Ehrlich ascites carcinoma (EAC) cells with multidrug resistance by holothurian triterpene glycoside, cucumarioside A2-2 (CA2-2) was evaluated. Calcein-AM efflux assay and doxorubicin (DOX) uptake and retention measurement in cancer cells, as well as determination [...] Read more.
The effect of treatment of Ehrlich ascites carcinoma (EAC) cells with multidrug resistance by holothurian triterpene glycoside, cucumarioside A2-2 (CA2-2) was evaluated. Calcein-AM efflux assay and doxorubicin (DOX) uptake and retention measurement in cancer cells, as well as determination of DOX cytotoxic and anticancer effects were applied. Treatment of EAC cells with CA2-2 (0.01–0.1 μM) blocked Calcein-AM and DOX efflux from cancer cells and increased the accumulation and cytotoxicity of DOX in EAC cells. Moreover, pre-treatment of mice with EAC by CA2-2 (10 μg/kg/5 days, intraperitoneal injection (i.p.)), then transplantation of tumor cells into fresh animals and subsequent treatment of these mice with DOX (2 mg/kg/3 days i.p.) significantly increased average life span (ALS) of mice bearing a tumor and therefore boosted the antitumor effect of doxorubicin in vivo. Full article
(This article belongs to the Special Issue Active Compounds from Sea Cucumber)
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