Marine Bioactive Compounds for Skin Health

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1717

Special Issue Editor


E-Mail Website
Guest Editor
College of Life Science, Gangneung-Wonju National University, Gangneung, Republic of Korea
Interests: natural products research; atopic dermatitis; inflammation; immunology; molecular biology

Special Issue Information

Dear Colleagues,

Population ageing makes people increasingly conscious about their health. The skin, one of the largest organs in the body, plays a critical role as a protective barrier that directly interacts with the external environment. Beyond its basic protective function, the skin performs various physiological functions, such as temperature regulation, moisture retention, and sensory perception. Moreover, the skin is a vital component of the body's immune system and protects against harmful substances and organisms such as bacteria and viruses.

Skin health is closely linked to overall well-being and is influenced by both external and internal factors. External factors include ultraviolet (UV) radiation, pollution, dry air, and chemical exposure, whereas internal factors include diet, stress, and hormonal changes.

The ocean, which covers 71% of the Earth's surface, is a vast and largely unexplored realm. It plays a crucial role in regulating the planet’s climate, supporting extensive ecosystems and providing valuable resources and services to human society. The ocean is home to a diverse range of organisms, from zooplankton to marine mammals, and it exhibits far greater biodiversity than terrestrial ecosystems. This diversity includes many undiscovered species and rare compounds with unique structures that hold great potential as molecular models for the synthesis of new pharmaceuticals.

This Special Issue focuses on the identification of active compounds derived from marine natural products and their biological mechanisms in relation to skin health. We encourage the inclusion of recent research findings, particularly those utilizing advanced research techniques, such as artificial skin models. The goal of this issue is to offer scientists in related fields and general readers easy access to the latest trends in marine-derived compounds for skin health.

Dr. Hyun Soo Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine bioactive compounds
  • marine metabolites
  • skin health
  • skin inflammation
  • marine pharmaceuticals

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 3455 KiB  
Article
Amelioration of Particulate Matter-Induced Oxidative Stress by a Bioactive Hizikia fusiformis Extract: A Functional Biomaterial for Cosmeceutical Applications
by Jeong Won Ahn, Hyun Soo Kim, So Hui Kim, Hye Soo Yang, Kongara Damodar, Yeong-Min Yoo, Jin Tae Hong and Seong Soo Joo
Mar. Drugs 2025, 23(3), 135; https://doi.org/10.3390/md23030135 - 20 Mar 2025
Viewed by 372
Abstract
Air pollution-related skin damage has heightened the demand for natural protective agents. Hizikia fusiformis, a brown seaweed rich in fucoidan and bioactive fatty acids (α-linolenic acid, eicosatetraenoic acid, and palmitic acid), possesses antioxidant and anti-inflammatory properties. This study investigated the protective effects [...] Read more.
Air pollution-related skin damage has heightened the demand for natural protective agents. Hizikia fusiformis, a brown seaweed rich in fucoidan and bioactive fatty acids (α-linolenic acid, eicosatetraenoic acid, and palmitic acid), possesses antioxidant and anti-inflammatory properties. This study investigated the protective effects of H. fusiformis ethanol extract (HFE) against particulate matter (PM)-induced oxidative stress, inflammation, and apoptosis in human keratinocytes. Antioxidant activity was assessed using DPPH and hydroxyl radical scavenging assays, while PM-induced cytotoxicity, ROS generation, inflammatory markers, and apoptotic pathways were evaluated using the WST-8 assay, DCFH2-DA, qPCR, western blotting, and Hoechst staining. HFE significantly reduced ROS levels, enhanced antioxidant enzyme activity, and mitigated PM-induced cytotoxicity. These effects were mediated by fucoidan and fatty acids, which modulated inflammatory pathways (NF-κB and MAPK), stabilized membranes, and inhibited apoptosis (Bcl-2, Bax, and caspase-3). Collectively, these findings highlight HFE’s potential as a natural anti-pollution skincare ingredient, supporting further in vivo studies and formulation development. Full article
(This article belongs to the Special Issue Marine Bioactive Compounds for Skin Health)
Show Figures

Figure 1

15 pages, 1727 KiB  
Article
Characterizing the Ultraviolet (UV) Screening Ability of L-5-Sulfanylhistidine Derivatives on Human Dermal Fibroblasts
by Alessia Luccarini, Fabio Marcheggiani, Roberta Galeazzi, Annalisa Zuccarotto, Immacolata Castellano and Elisabetta Damiani
Mar. Drugs 2025, 23(2), 57; https://doi.org/10.3390/md23020057 - 24 Jan 2025
Viewed by 1025
Abstract
Using sunscreens is one of the most widespread measures to protect human skin from sun ultraviolet radiation (UVR) damage. However, several studies have highlighted the toxicity of certain inorganic and organic UV filters used in sunscreens for the marine environment and human health. [...] Read more.
Using sunscreens is one of the most widespread measures to protect human skin from sun ultraviolet radiation (UVR) damage. However, several studies have highlighted the toxicity of certain inorganic and organic UV filters used in sunscreens for the marine environment and human health. An alternative strategy may involve the use of natural products of marine origin to counteract UVR-mediated damage. Ovothiols are sulfur-containing amino acids produced by marine invertebrates, microalgae, and bacteria, endowed with unique antioxidant and UV-absorption properties. This study aimed to evaluate the protective effect of synthetic L-5-sulfanyl histidine derivatives, inspired by natural ovothiols, on human dermal fibroblasts (HDFs) upon UVA exposure. By using a custom-made experimental set-up to assess the UV screening ability, we measured the levels of cytosolic and mitochondrial reactive oxygen species (ROS), as well as cell viability and apoptosis in HDFs, in the presence of tested compounds, after UVA exposure, using flow cytometry assays with specific fluorescent probes. The results show that L-5-sulfanyl histidine derivatives display a UV screening capacity and prevent loss in cell viability, the production of cytosolic and mitochondrial ROS induced by UVA exposure in HDFs, and subsequent apoptosis. Overall, this study sheds light on the potential applications of marine-inspired sulfur-containing amino acids in developing alternative eco-safe sunscreens for UVR skin protection. Full article
(This article belongs to the Special Issue Marine Bioactive Compounds for Skin Health)
Show Figures

Figure 1

Back to TopTop