Exploring New Approaches to Disease Treatment with Attenuated Salmonella
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 12
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bacterial vector-based therapies utilizing attenuated Salmonella strains have emerged as a transformative approach in medical treatment, particularly for targeted drug delivery, immunotherapy, and vaccine innovation. This Special Issue aims to showcase groundbreaking research dedicated to employing engineered Salmonella strains to address infectious diseases and cancer, while also serving as viable alternatives to antibiotics amid the escalating threat of antimicrobial resistance.
Attenuated Salmonella strains can be genetically manipulated to selectively deliver therapeutic payloads such as antigens, cytokines, or cytotoxic agents to specific tumor sites or immune-rich tissues, thereby enhancing therapeutic efficacy and reducing off-target effects. The bacteria's ability to provoke strong immune responses further positions it as a promising vehicle for next-generation vaccines and immunotherapies.
The rationale behind this Special Issue arises from the urgent need for innovative therapies that overcome the limitations associated with conventional treatment modalities, including issues of drug resistance, systemic toxicity, and suboptimal bioavailability. Insights into the mechanistic pathways and efficacy of these engineered strains will be critical in advancing clinical applications in the near future.
We invite submissions that encompass a wide range of topics, including (but not limited to):
- The molecular engineering of attenuated Salmonella for therapeutic delivery.
- Mechanisms of immune modulation by Salmonella-based therapies.
- Preclinical and clinical evaluations of Salmonella vectors in cancer and infectious diseases.
- Development and optimization of live attenuated Salmonella vaccines.
- Strategies to overcome challenges such as vaccine reversion and host immune evasion.
- Biosafety considerations and regulatory challenges.
Dr. Chamith Hewawaduge
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- attenuated salmonella
- vaccine development
- bacterial therapy
- cancer immunotherapy
- targeted drug delivery
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