Special Issue "Fatty Liver Syndrome"
Deadline for manuscript submissions: closed (25 August 2020).
2. Japan Strategic Medical Administration Research Center (J-SMARC), Nagoya, Aichi, Japan
Interests: nonalcoholic steatohepatitis; oxidative stress; hepatic fibrosis; diabetes mellitus; liver cirrhosis; hepatocellular carcinoma
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Diabetic Liver Disease
Special Issue in Life: Diabetic Liver Disease
Special Issue in Gastroenterology Insights: Fatty Liver Syndrome
Fatty liver disease is the most prevalent chronic liver disease worldwide. Fatty liver disease is induced by a variety of factors, such as alcohol intake, obesity, diabetes, hepatic virus C infection, endocrine disorder (growth hormone deficiency, testosterone deficiency, hypothyroidism), operation (pancreatoduodenectomy, ilio-cecal bypass), drugs (tamoxifen, methotrexate, steroids, etc.), and genetic polymorphism (PNPLA3, TM6SF2 etc.). Accumulating evidence has established that PNPLA3 SNP is closely associated with fibrosis progression or HCC development in FLS. The term “nonalcoholic fatty liver disease” (NAFLD) was coined by Schaffner, and has been used for a few decades. We do not know how obese patients that are mild drinkers (210~300 g/wk) showing steatohepatitis should be categorized. Both associated steatohepatitis (BASH) has been suggested in this case. It is time to abandon the term “NAFLD and AFLD”. Therefore, we would like to suggest that fatty liver disease can be called “fatty liver syndrome” (FALIS). This Special Issue welcomes original research and review paper regarding FALIS.
- Mechanisms of insulin resistance and hepatic steatosis/fibrosis;
- The role of alcohol in FLS;
- The role of SNPs with disease severity in FLS;
- The role of microbiota in FLS;
- Endocrine disorder in FLS;
- Drug-induced FLS;
- The role of iron metabolism in FLS;
- Antifibrotic agents in FLS;
- How can we stop HCC development in FLS?
- Mechanisms of cardiac/renal disease and FLS;
- Treatment strategy or pipelines for FLS;
- Noninvasive tests (NITs) of hepatic fibrosis in FLS;
- Liver transplantation for FLS.
Assoc. Prof. Dr. Yoshio Sumida
Manuscript Submission Information
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