Cardiovascular Tissue Engineering: Current Status and Advances

Dear Colleagues,

Cardiovascular tissue engineering has emerged as one of the most promising fields in cardiovascular research, integrating the scientific disciplines of biology, physics, materials science, and biomedical engineering. It continues to evolve, with regular updates of information being highly valuable. Functional biomaterial systems are designed, manufactured, and used with various advanced tissue manufacturing methods to replicate the extracellular matrix of cardiac tissue. These cardiac biomaterials influence cellular behavior through complex sequences of physical and biochemical cues. The morphology and properties of cardiac or vascular scaffolds affect processes such as cell adhesion, proliferation, differentiation, and function. In artificial bioengineering environments, cardiac and vascular cells have the potential to proliferate into functional tissues suitable for implantation. Despite advancements, cardiovascular diseases remain a significant cause of mortality, and this emphasizes the urgent need for early clinical applications in cardiovascular regenerative medicine.

This Special Issue focuses on analyzing the latest advancements in cardiovascular regenerative medicine, particularly in the engineering of cardiovascular tissues for in vitro disease modeling, drug screening, and in vivo regenerative applications. It includes detailed discussions on various biomaterials, cells, hybrid mechanisms, and the latest imaging evaluation methods or computational modeling related to the regeneration process. Contributions are also welcomed on advanced large animal experiments nearing completion and clinical trials approaching application. We look forward to receiving submissions.

Dr. Yuichi Matsuzaki
Dr. Ilia Fishbein
Guest Editors

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